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The reign of the p-value is over: what alternative analyses could we employ to fill the power vacuum?
The p-value has long been the figurehead of statistical analysis in biology, but its position is
under threat. p is now widely recognized as providing quite limited information about our …
under threat. p is now widely recognized as providing quite limited information about our …
Organic Bioelectronics for In Vitro Systems
Bioelectronics have made strides in improving clinical diagnostics and precision medicine.
The potential of bioelectronics for bidirectional interfacing with biology through continuous …
The potential of bioelectronics for bidirectional interfacing with biology through continuous …
[HTML][HTML] Animal-derived products in science and current alternatives
More than fifty years after the 3Rs definition and despite the continuous implementation of
regulatory measures, animals continue to be widely used in basic research. Their use …
regulatory measures, animals continue to be widely used in basic research. Their use …
Towards more compassionate wildlife research through the 3Rs principles: Moving from invasive to non‐invasive methods
Research in ecology and wildlife biology remains crucial for increasing our knowledge and
improving species management and conservation in the midst of the current biodiversity …
improving species management and conservation in the midst of the current biodiversity …
The welfare and ethics of research involving wild animals: A primer
Wild animals are used in scientific research in a wide variety of contexts both in situ and ex
situ. Guidelines for best practice, where they exist, are not always clearly linked to animal …
situ. Guidelines for best practice, where they exist, are not always clearly linked to animal …
[HTML][HTML] The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function
Numerous neurodegenerative and psychiatric disorders are associated with deficits in
executive functions such as working memory and cognitive flexibility. Progress in develo** …
executive functions such as working memory and cognitive flexibility. Progress in develo** …
Daphnia as a model organism to probe biological responses to nanomaterials—from individual to population effects via adverse outcome pathways
The importance of the cladoceran Daphnia as a model organism for ecotoxicity testing has
been well-established since the 1980s. Daphnia have been increasingly used in …
been well-established since the 1980s. Daphnia have been increasingly used in …
Antibody-mediated protection against Ebola virus
Recent Ebola virus disease epidemics have highlighted the need for effective vaccines and
therapeutics to prevent future outbreaks. Antibodies are clearly critical for control of this …
therapeutics to prevent future outbreaks. Antibodies are clearly critical for control of this …
Animal models of pain: diversity and benefits
Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to develo** …
deepening of our knowledge on mechanisms that cause pain is a prerequisite to develo** …
[HTML][HTML] Using chemical and biological data to predict drug toxicity
Various sources of information can be used to better understand and predict compound
activity and safety-related endpoints, including biological data such as gene expression and …
activity and safety-related endpoints, including biological data such as gene expression and …