Adaptive quantum/molecular mechanics: what have we learned, where are we, and where do we go from here?

AW Duster, CH Wang, CM Garza… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Adaptive quantum‐mechanics/molecular‐mechanics (QM/MM) methods feature on‐the‐fly
reclassification of atoms as QM or MM during a molecular dynamics (MD) simulation …

Tracking the delocalized proton in concerted proton transfer in bulk water

S Yan, B Wang, H Lin - Journal of Chemical Theory and …, 2023 - ACS Publications
A solvated proton in water is often characterized as a charge or structural defect, and it is
important to track its evolution on-the-fly in certain dynamics simulations. Previously, we …

Adaptive-partitioning multilayer dynamics simulations: 2. Implementations of the permuted and interpolated adaptive-partitioning gradients

AL Tran, EB Guidez, H Lin - The Journal of Physical Chemistry A, 2023 - ACS Publications
Recently, an adaptive-partitioning multilayer Q1/Q2/MM method was proposed, where Q1
and Q2 denote, respectively, two distinct quantum-mechanical levels of theory and MM, the …

Adaptive partitioning QM/MM for molecular dynamics simulations: 6. Proton transport through a biological channel

AW Duster, CM Garza, BO Aydintug… - Journal of chemical …, 2019 - ACS Publications
Adaptive quantum-mechanics/molecular-mechanics (QM/MM) dynamics simulations feature
on-the-fly reclassification of atoms as QM or MM continuously and smoothly as trajectories …

Tracking proton transfer through titratable amino acid side chains in adaptive QM/MM simulations

AW Duster, H Lin - Journal of Chemical Theory and Computation, 2019 - ACS Publications
Ubiquitous throughout biological processes, proton transport usually occurs through the
Grotthuss shuttling mechanism, where the hydrated proton exists as a charge or structural …

Adaptive QM/MM for molecular dynamics simulations: 5. On the energy-conserved permuted adaptive-partitioning schemes

AW Duster, CH Wang, H Lin - Molecules, 2018 - mdpi.com
In combined quantum-mechanical/molecular-mechanical (QM/MM) dynamics simulations,
the adaptive-partitioning (AP) schemes reclassify atoms on-the-fly as QM or MM in a smooth …

Adaptive-partitioning multilayer dynamics simulations: 1. On-the-fly switch between two quantum levels of theory

J Mato, AW Duster, EB Guidez… - Journal of chemical theory …, 2021 - ACS Publications
We propose to generalize the previously developed two-layer permuted adaptive-
partitioning quantum-mechanics/molecular-mechanics (QM/MM), which reclassifies atoms …

Resha** the QM Region On-the-Fly: Adaptive-Shape QM/MM Dynamic Simulations of a Hydrated Proton in Bulk Water

S Yan, B Wang, H Lin - Journal of Chemical Theory and …, 2024 - ACS Publications
Adaptive quantum mechanics/molecular mechanics (QM/MM) reclassifies on-the-fly a
molecule or molecular fragment as QM or MM during dynamics simulations without abrupt …

A benchmark study of kinetic isotope effects and barrier heights for the Finkelstein reaction

S Zaczek, F Gelman… - The Journal of Physical …, 2017 - ACS Publications
Herein, we present a combined (experimental and computational) study of the Finkelstein
reaction in condensed phase, where bromine is substituted by iodine in 2 …

On-the-fly determination of active region centers in adaptive-partitioning QM/MM

Z Yang - Physical Chemistry Chemical Physics, 2020 - pubs.rsc.org
Quantum mechanics/molecular mechanics (QM/MM) methods are widely used in molecular
dynamics (MD) simulations of large systems. By partitioning the system into active and …