[HTML][HTML] Cytotoxicity of dendrimers

A Janaszewska, J Lazniewska, P Trzepiński… - Biomolecules, 2019‏ - mdpi.com
Drug delivery systems are molecular platforms in which an active compound is packed into
or loaded on a biocompatible nanoparticle. Such a solution improves the activity of the …

[HTML][HTML] Dendrimers in the context of nanomedicine

AP Dias, S da Silva Santos, JV da Silva… - International journal of …, 2020‏ - Elsevier
Dendrimers are globular structures, presenting an initiator core, repetitive layers starting
radially from the core and terminal groups on the surface, resembling tree architecture …

Overcoming the blood–brain barrier. challenges and tricks for CNS drug delivery

LA Bors, F Erdő - Scientia Pharmaceutica, 2019‏ - mdpi.com
Treatment of certain central nervous system disorders, including different types of cerebral
malignancies, is limited by traditional oral or systemic administrations of therapeutic drugs …

[HTML][HTML] Dendrimer-based drug delivery systems for brain targeting

Y Zhu, C Liu, Z Pang - Biomolecules, 2019‏ - mdpi.com
Human neuroscience has made remarkable progress in understanding basic aspects of
functional organization; it is a renowned fact that the blood–brain barrier (BBB) impedes the …

Nanotechnology-based drug delivery systems for Alzheimer's disease management: Technical, industrial, and clinical challenges

MM Wen, NS El-Salamouni, WM El-Refaie… - Journal of controlled …, 2017‏ - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease with high prevalence in the
rapidly growing elderly population in the develo** world. The currently FDA approved …

siRNA drug delivery across the blood–brain barrier in Alzheimer's disease

MI Sajid, FS Sheikh, F Anis, N Nasim… - Advanced drug delivery …, 2023‏ - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a few FDA-
approved drugs that provide modest symptomatic benefits and only two FDA-approved …

Dendrimers and hyperbranched structures for biomedical applications

E Pedziwiatr-Werbicka, K Milowska, V Dzmitruk… - European Polymer …, 2019‏ - Elsevier
The use of nanotechnology in biology and medicine has been marked by rapid progress of
these industries due to the emergence of new devices, supramolecular systems, structures …

Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment

M Kaurav, S Ruhi, HA Al-Goshae, AK Jeppu… - Frontiers in …, 2023‏ - frontiersin.org
A brain tumor is an uncontrolled cell proliferation, a mass of tissue composed of cells that
grow and divide abnormally and appear to be uncontrollable by the processes that normally …

Molecular insights into the phase transition of lysozyme into amyloid nanostructures: Implications of therapeutic strategies in diverse pathological conditions

S Roy, VR Srinivasan, S Arunagiri, N Mishra… - Advances in Colloid and …, 2024‏ - Elsevier
Lysozyme, a well-known bacteriolytic enzyme, exhibits a fascinating yet complex behavior
when it comes to protein aggregation. Under certain conditions, this enzyme undergoes …

Dendrimer advances for the central nervous system delivery of therapeutics

L Xu, H Zhang, Y Wu - ACS chemical neuroscience, 2014‏ - ACS Publications
The effectiveness of noninvasive treatment for central nervous system (CNS) diseases is
generally limited by the poor access of therapeutic agents into the CNS. Most CNS drugs …