Autosomal-recessive cerebellar ataxias (ARCAs) comprise a heterogeneous group of rare
degenerative and metabolic genetic diseases that share the hallmark of progressive …

Friedreich ataxia (FRDA) is an autosomal recessive inherited multisystem disease,
characterized by marked differences in the vulnerability of neuronal systems. In general, the …

Objective Friedreich ataxia (FRDA) is an inherited neurological disease defined by
progressive movement incoordination. We undertook a comprehensive characterization of …

Summary Background The European Friedreich's Ataxia Consortium for Translational
Studies (EFACTS) investigates the natural history of Friedreich's ataxia. We aimed to assess …

Background and Objectives Friedreich ataxia (FRDA) is an autosomal recessive ataxia with
no approved treatments. Leriglitazone is a selective peroxisome proliferator–activated …

The cerebellar nuclei are a brain region with high iron content. Surprisingly, little is known
about iron content in the cerebellar nuclei and its possible contribution to pathology in …

Background Spinal cord damage is a hallmark of Friedreich's ataxia (FRDA), but its
progression and clinical correlates remain unclear. Objective The objective of this study was …

Background and purpose Friedreich's ataxia (FRDA) is the most common autosomal‐
recessive ataxia worldwide. It is characterized by early onset, sensory abnormalities and …

Background Study the cognitive profile of individuals with Friedreich ataxia (FRDA) and seek
evidence for correlations between clinical, genetic and imaging characteristics and …

Friedreich ataxia (FRDA) is a recessive disorder resulting from relative deficiency of the
mitochondrial protein frataxin. Frataxin functions in the process of iron–sulfur (Fe–S) cluster …