The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
The blood–brain barrier and blood–tumour barrier in brain tumours and metastases
For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …
Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options
Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …
The microenvironmental landscape of brain tumors
DF Quail, JA Joyce - Cancer cell, 2017 - cell.com
The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer
progression in primary and metastatic brain malignancies. The unique properties of this …
progression in primary and metastatic brain malignancies. The unique properties of this …
The blood-brain barrier: Physiology and strategies for drug delivery
The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper,
reflecting the unique requirements of the brain. In this review, following a brief historical …
reflecting the unique requirements of the brain. In this review, following a brief historical …
Overcoming the blood–brain barrier: the role of nanomaterials in treating neurological diseases
Therapies directed toward the central nervous system remain difficult to translate into
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …
Targeting and crossing the blood-brain barrier with extracellular vesicles
J Saint-Pol, F Gosselet, S Duban-Deweer, G Pottiez… - Cells, 2020 - mdpi.com
The blood–brain barrier (BBB) is one of the most complex and selective barriers in the
human organism. Its role is to protect the brain and preserve the homeostasis of the central …
human organism. Its role is to protect the brain and preserve the homeostasis of the central …
The role of brain barriers in fluid movement in the CNS: is there a 'glymphatic'system?
Brain fluids are rigidly regulated to provide stable environments for neuronal function, eg,
low K+, Ca 2+, and protein to optimise signalling and minimise neurotoxicity. At the same …
low K+, Ca 2+, and protein to optimise signalling and minimise neurotoxicity. At the same …
Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection
W Abdullahi, D Tripathi… - American Journal of …, 2018 - journals.physiology.org
The blood-brain barrier (BBB) is a physical and biochemical barrier that precisely controls
cerebral homeostasis. It also plays a central role in the regulation of blood-to-brain flux of …
cerebral homeostasis. It also plays a central role in the regulation of blood-to-brain flux of …
Blood–brain barrier breakdown: an emerging biomarker of cognitive impairment in normal aging and dementia
B Hussain, C Fang, J Chang - Frontiers in neuroscience, 2021 - frontiersin.org
The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …