Background: Conditions of excess androgen in women, such as polycystic ovary syndrome
(PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS …

During the last two decades, significant progress in our understanding of the development of
kidney diseases has been achieved by unravelling the mechanisms underlying rare familial …

A disintegrin-like metalloproteinase with thrombospondin motifs–16 (Adamts16) is an
important candidate gene for hypertension. The goal of the present study was to further …

Clinical studies indicate that smoking combustible cigarettes promotes progression of renal
and cardiac injury, leading to functional decline in the setting of chronic kidney disease …

Multiple GWAS studies have reported strong association of cardiac QT-interval to a region
on HSA17. Interestingly, a rat locus homologous to this region is also linked to QT-intervals …

After graduating from high school, Dr Lewis Dahl moved to Seattle, Washington, to complete
his undergraduate studies at the University of Washington in 1935 (Figure 2). He then …

Background Sodium glucose co-transporter 2 inhibitors (SGLT2is) are a novel class of oral
antidiabetic drugs. To date, there are no pharmacoepidemiologic studies investigating the …

Cell death has long been a characteristic phenotype of organ damage in hypertension, and
recently, leaky gut has been revealed as a novel hypertensive phenotype. However, despite …

Genome-wide association studies (GWAS) have prioritized a transcription factor, nuclear
receptor 2 family 2 (NR2F2), as being associated with essential hypertension in humans …

Background Renal artery stenosis is a common cause of renal ischemia, contributing to the
development of chronic kidney disease. To investigate the role of local CD 40 expression in …