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Emerging approaches to DNA data storage: challenges and prospects
With the total amount of worldwide data skyrocketing, the global data storage demand is
predicted to grow to 1.75× 1014 GB by 2025. Traditional storage methods have difficulties …
predicted to grow to 1.75× 1014 GB by 2025. Traditional storage methods have difficulties …
DNA origami
Biological materials are self-assembled with near-atomic precision in living cells, whereas
synthetic 3D structures generally lack such precision and controllability. Recently, DNA …
synthetic 3D structures generally lack such precision and controllability. Recently, DNA …
SELFIES and the future of molecular string representations
Artificial intelligence (AI) and machine learning (ML) are expanding in popularity for broad
applications to challenging tasks in chemistry and materials science. Examples include the …
applications to challenging tasks in chemistry and materials science. Examples include the …
Nucleic acid tests for clinical translation
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …
natural biopolymers composed of nucleotides that store, transmit, and express genetic …
Spontaneous driving forces give rise to protein− RNA condensates with coexisting phases and complex material properties
Phase separation of multivalent protein and RNA molecules underlies the biogenesis of
biomolecular condensates such as membraneless organelles. In vivo, these condensates …
biomolecular condensates such as membraneless organelles. In vivo, these condensates …
Bioinspired and biomimetic delivery platforms for cancer vaccines
Cancer vaccines aim at eliciting tumor‐specific responses for the immune system to identify
and eradicate malignant tumor cells while sparing the normal tissues. Furthermore, cancer …
and eradicate malignant tumor cells while sparing the normal tissues. Furthermore, cancer …
Self-assembling nucleic acid nanostructures functionalized with aptamers
Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …
would allow artificial biopolymer complexes to self-assemble and function similarly to the …
Building machines with DNA molecules
H Ramezani, H Dietz - Nature Reviews Genetics, 2020 - nature.com
In nature, DNA molecules carry the hereditary information. But DNA has physical and
chemical properties that make it attractive for uses beyond heredity. In this Review, we …
chemical properties that make it attractive for uses beyond heredity. In this Review, we …
A DNA origami‐based gene editing system for efficient gene therapy in vivo
W Tang, T Tong, H Wang, X Lu, C Yang… - Angewandte Chemie …, 2023 - Wiley Online Library
DNA nanostructures have played an important role in the development of novel drug
delivery systems. Herein, we report a DNA origami‐based CRISPR/Cas9 gene editing …
delivery systems. Herein, we report a DNA origami‐based CRISPR/Cas9 gene editing …
Genetically encoded DNA origami for gene therapy in vivo
X Wu, C Yang, H Wang, X Lu, Y Shang… - Journal of the …, 2023 - ACS Publications
DNA origami has played an important role in various biomedical applications, including
biosensing, bioimaging, and drug delivery. However, the function of the long DNA scaffold …
biosensing, bioimaging, and drug delivery. However, the function of the long DNA scaffold …