Emerging approaches to DNA data storage: challenges and prospects

A Doricchi, CM Platnich, A Gimpel, F Horn, M Earle… - ACS …, 2022 - ACS Publications
With the total amount of worldwide data skyrocketing, the global data storage demand is
predicted to grow to 1.75× 1014 GB by 2025. Traditional storage methods have difficulties …

DNA origami

S Dey, C Fan, KV Gothelf, J Li, C Lin, L Liu… - Nature Reviews …, 2021 - nature.com
Biological materials are self-assembled with near-atomic precision in living cells, whereas
synthetic 3D structures generally lack such precision and controllability. Recently, DNA …

SELFIES and the future of molecular string representations

M Krenn, Q Ai, S Barthel, N Carson, A Frei, NC Frey… - Patterns, 2022 - cell.com
Artificial intelligence (AI) and machine learning (ML) are expanding in popularity for broad
applications to challenging tasks in chemistry and materials science. Examples include the …

Nucleic acid tests for clinical translation

M Li, F Yin, L Song, X Mao, F Li, C Fan, X Zuo… - Chemical …, 2021 - ACS Publications
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

Spontaneous driving forces give rise to protein− RNA condensates with coexisting phases and complex material properties

S Boeynaems, AS Holehouse, V Weinhardt… - Proceedings of the …, 2019 - pnas.org
Phase separation of multivalent protein and RNA molecules underlies the biogenesis of
biomolecular condensates such as membraneless organelles. In vivo, these condensates …

Bioinspired and biomimetic delivery platforms for cancer vaccines

J Liu, SS Liew, J Wang, K Pu - Advanced Materials, 2022 - Wiley Online Library
Cancer vaccines aim at eliciting tumor‐specific responses for the immune system to identify
and eradicate malignant tumor cells while sparing the normal tissues. Furthermore, cancer …

Self-assembling nucleic acid nanostructures functionalized with aptamers

A Krissanaprasit, CM Key, S Pontula… - Chemical …, 2021 - ACS Publications
Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …

Building machines with DNA molecules

H Ramezani, H Dietz - Nature Reviews Genetics, 2020 - nature.com
In nature, DNA molecules carry the hereditary information. But DNA has physical and
chemical properties that make it attractive for uses beyond heredity. In this Review, we …

A DNA origami‐based gene editing system for efficient gene therapy in vivo

W Tang, T Tong, H Wang, X Lu, C Yang… - Angewandte Chemie …, 2023 - Wiley Online Library
DNA nanostructures have played an important role in the development of novel drug
delivery systems. Herein, we report a DNA origami‐based CRISPR/Cas9 gene editing …

Genetically encoded DNA origami for gene therapy in vivo

X Wu, C Yang, H Wang, X Lu, Y Shang… - Journal of the …, 2023 - ACS Publications
DNA origami has played an important role in various biomedical applications, including
biosensing, bioimaging, and drug delivery. However, the function of the long DNA scaffold …