The electromechanical function of the heart involves complex, coordinated activity over time
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …

Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Electrode-based electrical stimulation underpins several clinical bioelectronic devices,
including deep-brain stimulators, and cardiac pacemakers. However, leadless multisite …

Optogenetics is an elegant approach of precisely controlling and monitoring the biological
functions of a cell, group of cells, tissues, or organs with high temporal and spatial resolution …

Optogenetic techniques permit studies of excitable tissue through genetically expressed
light-gated microbial channels or pumps permitting transmembrane ion movement. Light …

The ability to record and analyse electrical behaviour across the heart using optical and
electrode map** has revolutionised cardiac research. However, wider uptake of these …

Since mammalian tissue is relatively transparent to near-infrared (NIR) light, NIR fluorescent
proteins (FPs) engineered from bacterial phytochromes have become widely used probes …

Deep Brain Stimulation (DBS) has evolved into a well-accepted add-on treatment for
patients with severe Parkinsons disease as well as for other chronic neurological conditions …

The growing importance of human induced pluripotent stem cell-derived cardiomyoyctes
(hiPSC-CMs), as patient-specific and disease-specific models for studying cellular cardiac …

Cardiac action potential (AP) shape and propagation are regulated by several key dynamic
factors such as ion channel recovery and intracellular Ca2+ cycling. Experimental methods …