How electroconvulsive therapy works in the treatment of depression: is it the seizure, the electricity, or both?

ZD Deng, PL Robins, W Regenold, P Rohde… - …, 2024 - nature.com
We have known for nearly a century that triggering seizures can treat serious mental illness,
but what we do not know is why. Electroconvulsive Therapy (ECT) works faster and better …

[HTML][HTML] Adult neurogenesis, human after all (again): Classic, optimized, and future approaches

PJ Lucassen, CP Fitzsimons, E Salta… - Behavioural brain …, 2020 - Elsevier
In this perspective article, we reflect on the recent debate about the existence of human
neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and …

[HTML][HTML] Volume of the human hippocampus and clinical response following electroconvulsive therapy

L Oltedal, KL Narr, C Abbott, A Anand, M Argyelan… - Biological …, 2018 - Elsevier
Background Hippocampal enlargements are commonly reported after electroconvulsive
therapy (ECT). To clarify mechanisms, we examined if ECT-induced hippocampal volume …

Electroconvulsive therapy, electric field, neuroplasticity, and clinical outcomes

ZD Deng, M Argyelan, J Miller, DK Quinn, M Lloyd… - Molecular …, 2022 - nature.com
Electroconvulsive therapy (ECT) remains the gold-standard treatment for patients with
depressive episodes, but the underlying mechanisms for antidepressant response and …

Electroconvulsive therapy increases brain volume in major depression: a systematic review and meta‐analysis

K Gbyl, P Videbech - Acta Psychiatrica Scandinavica, 2018 - Wiley Online Library
Objective The main purpose of this review was to synthesise evidence on ECT's effects on
brain's structure. Method A systematic literature review of longitudinal studies of depressed …

Effect of electroconvulsive therapy on hippocampal and amygdala volumes: systematic review and meta-analysis

A Takamiya, JK Chung, K Liang… - The British Journal of …, 2018 - cambridge.org
BackgroundElectroconvulsive therapy (ECT) is one of the most effective treatments for
depression, although the underlying mechanisms remain unclear. Animal studies have …

[HTML][HTML] The neurobiological effects of electroconvulsive therapy studied through magnetic resonance: what have we learned, and where do we go?

OT Ousdal, GE Brancati, U Kessler, V Erchinger… - Biological …, 2022 - Elsevier
Electroconvulsive Therapy (ECT) is an established treatment choice for severe, treatment-
resistant depression, yet its mechanisms of action remain elusive. Magnetic resonance …

Brain gray matter alterations in first episodes of depression: a meta-analysis of whole-brain studies

H Zhang, L Li, M Wu, Z Chen, X Hu, Y Chen… - Neuroscience & …, 2016 - Elsevier
Though numerous studies have implicated structural abnormalities in chronically depressive
patients, relatively little attention has been paid to the brain alterations in patients …

[HTML][HTML] Brain changes induced by electroconvulsive therapy are broadly distributed

OT Ousdal, M Argyelan, KL Narr, C Abbott, B Wade… - Biological …, 2020 - Elsevier
Background Electroconvulsive therapy (ECT) is associated with volumetric enlargements of
corticolimbic brain regions. However, the pattern of whole-brain structural alterations …

Brain structural effects of treatments for depression and biomarkers of response: a systematic review of neuroimaging studies

V Enneking, EJ Leehr, U Dannlowski… - Psychological …, 2020 - cambridge.org
Antidepressive pharmacotherapy (AD), electroconvulsive therapy (ECT) and cognitive
behavioural therapy (CBT) are effective treatments for major depressive disorder. With our …