The role of platelets in heat-related illness and heat-induced coagulopathy
Heat-related illness is becoming more problematic due to ongoing global warming. Heat-
related injury causes systemic inflammation and coagulopathy, due to leukocyte, platelet …
related injury causes systemic inflammation and coagulopathy, due to leukocyte, platelet …
Inflammasome signaling, thromboinflammation, and venous thromboembolism
Venous thromboembolism (VTE) remains a major health burden despite anticoagulation
advances, suggesting incomplete management of pathogenic mechanisms. The NLRP3 …
advances, suggesting incomplete management of pathogenic mechanisms. The NLRP3 …
Colchicine as a modulator of platelet function: a systematic review
The microtubule inhibitor and anti-inflammatory agent colchicine is used to treat a range of
conditions involving inflammasome activation in monocytes and neutrophils, and is now …
conditions involving inflammasome activation in monocytes and neutrophils, and is now …
Megakaryocyte NLRP3 hyperactivation induces mild anemia and potentiates inflammatory response in mice
JH Bourne, J Campos, SJ Hopkin, K Whitworth… - Frontiers in …, 2023 - frontiersin.org
Background The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3)
inflammasome has been described in both immune cells and platelets, but its role in the …
inflammasome has been described in both immune cells and platelets, but its role in the …
Identification of a Distinct Platelet Phenotype in the Elderly: ADP Hypersensitivity Coexists With Platelet PAR (Protease-Activated Receptor)-1 and PAR-4–Mediated …
Background: Thrombin (via PAR [protease-activated receptor]-1 and PAR-4) and ADP (via
P2Y12 receptors) are potent endogenous platelet activators implicated in the development …
P2Y12 receptors) are potent endogenous platelet activators implicated in the development …
Inflammasome-Independent Mechanism of NLRP3 Is Critical for Platelet GPIb-IX Function and Thrombosis
X Chen, J Li, P Liu, Y Zhou, T Zhang… - Thrombosis and …, 2024 - thieme-connect.com
Introduction Platelets link thrombosis and inflammation, but how platelets handle the
endogenous intraplatelet inflammatory machinery is less well understood. NACHT, LRR …
endogenous intraplatelet inflammatory machinery is less well understood. NACHT, LRR …
Short-Term Mortality in Hospitalized Patients with Congestive Heart Failure: Markers of Thrombo-Inflammation Are Independent Risk Factors and Only Weakly …
J Iglesias, N Okoh, SP Ang, CA Rodriguez… - Journal of …, 2024 - mdpi.com
Congestive heart failure (CHF) is associated with significant morbidity and mortality. There
has been renewed interest in using thrombo-inflammatory markers as prognostic tools in …
has been renewed interest in using thrombo-inflammatory markers as prognostic tools in …
NLRP3: More than an Inflammasome?
GJ Pennings - Thrombosis and Haemostasis, 2024 - thieme-connect.com
NLR family pyrin domain containing protein (NLRP) 3 is part of the NLRP3 inflammasome
complex which is formed between NLRP3, the adaptor protein apoptosis-associated speck …
complex which is formed between NLRP3, the adaptor protein apoptosis-associated speck …
Platelets from patients with chronic inflammation have a phenotype of chronic IL-1β release
M Berger, H Maqua, K Lysaja, SF Mause… - Research and practice …, 2024 - Elsevier
Background Chronic inflammation is a cardiovascular risk factor, and interleukin-1β (IL-1β)
is central to the inflammatory host response. Platelets contain the NLRP3 inflammasome …
is central to the inflammatory host response. Platelets contain the NLRP3 inflammasome …
Megakaryocyte NLRP3 hyperactivation induces anemia and potentiates inflammatory response in mice
A Brill, J Bourne, J Campos, S Hopkin, K Whitworth… - 2023 - researchsquare.com
The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome has been
described in both immune cells and platelets but its role in the megakaryocyte (MK) lineage …
described in both immune cells and platelets but its role in the megakaryocyte (MK) lineage …