In cells at steady state, two forms of cell compartmentalization coexist: membrane‐bound
organelles and phase‐separated membraneless organelles that are present in both the …

Emerging studies reveal that neurodegenerative disorders, including amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD), are commonly linked to DNA damage …

Eukaryotic initiation factor 2B, eIF2B is a guanine nucleotide exchange, factor with a central
role in coordinating the initiation of translation. During stress and disease, the activity of …

Membraneless condensates, such as stress granules (SGs) and processing bodies (P-
bodies), have attracted wide attention due to their unique feature of rapid response to stress …

Glucose is one of the most important sources of carbon across all life. Glucose starvation is a
key stress relevant to all eukaryotic cells. Glucose starvation responses have important …

The integrated stress response (ISR) is a conserved mechanism by which eukaryotic cells
remodel gene expression to adapt to intrinsic and extrinsic stressors rapidly and reversibly …

Vanishing white matter disease (VWM) is a severe leukodystrophy of the central nervous
system caused by mutations in subunits of the eukaryotic initiation factor 2B complex …

The discovery of intrinsically disordered proteins (IDPs) that do not have an ordered
structure and nevertheless perform essential functions has opened a new era in the …

Stress granules are phase-separated assemblies formed around RNAs. So far, the
techniques available to identify these RNAs are not suitable for single cells and small …

Eukaryotic initiation factor 2 (eIF2) is a G protein critical for translation. It is tightly regulated
in the integrated stress response (ISR) via phosphorylation of eIF2α and the subsequent …