Despite being empirically designed based on a simple understanding of TCR signaling, T
cells engineered with chimeric antigen receptors (CARs) have been remarkably successful …

The T-cell receptor (TCR)-CD3 complex serves as a central paradigm for general principles
of receptor assembly, ligand recognition, and signaling in the immune system. There is no …

To enhance the therapeutic index of T-cell engagers (TCEs), we engineered masked,
precision-activated TCEs (XPAT proteins), targeting a tumor antigen (human epidermal …

The T cell receptor (TCR) serves a critical function in the immune system and represents one
of the most complex receptor structures. A striking feature is the presence of nine highly …

We here defined the impacts of γ-secretase inhibitors (GSIs) on T-cell-dependent BCMA-
specific multiple myeloma (MM) cell lysis and immunomodulatory effects induced by …

Mature T cells are essential components of the immune system. They represent
phenotypically and functionally heterogenous populations of lymphocytes that are equipped …

Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor
(TCR) complex is involved in signal transduction. However, the function of the remaining …

▪ Abstract Recent studies have demonstrated that cell membranes provide a unique
environment for protein-protein and protein-lipid interactions that are critical for the assembly …

ABSTRACT T-cell-recruiting bispecific antibodies (T-BsAbs) have shown potent tumor killing
activity in humans, but cytokine release-related toxicities have affected their clinical utility …

VISUAL acuity depends on the fine-grained neural image set by the foveal cone mosaic1–3.
To preserve this spatial detail, cones transmit through non-divergent pathways: cone→ …