[HTML][HTML] The role of the ALK receptor in cancer biology
B Hallberg, RH Palmer - Annals of Oncology, 2016 - Elsevier
ABSTRACT A vast array of oncogenic variants has been identified for anaplastic lymphoma
kinase (ALK). Therefore, there is a need to better understand the role of ALK in cancer …
kinase (ALK). Therefore, there is a need to better understand the role of ALK in cancer …
Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
B Hallberg, RH Palmer - Nature Reviews Cancer, 2013 - nature.com
The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …
EML4-ALK enhances programmed cell death-ligand 1 expression in pulmonary adenocarcinoma via hypoxia-inducible factor (HIF)-1α and STAT3
ABSTRACT Programmed cell death (PD)-1/PD-1 ligand-1 (PD-L1)-targeted therapy has
emerged as a promising therapeutic strategy for lung cancer. However, whether EML4-ALK …
emerged as a promising therapeutic strategy for lung cancer. However, whether EML4-ALK …
STAT3 in cancer—friend or foe?
The roles and significance of STAT3 in cancer biology have been extensively studied for
more than a decade. Mounting evidence has shown that constitutive activation of STAT3 is a …
more than a decade. Mounting evidence has shown that constitutive activation of STAT3 is a …
[HTML][HTML] Anaplastic large cell lymphoma: molecular pathogenesis and treatment
Simple Summary Anaplastic large cell lymphoma is a rare type of disease that occurs
throughout the world and has four subtypes. A summary and comparison of these subtypes …
throughout the world and has four subtypes. A summary and comparison of these subtypes …
Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase physiologically expressed
by fetal neural cells. However, aberrantly expressed ALK is involved in the pathogenesis of …
by fetal neural cells. However, aberrantly expressed ALK is involved in the pathogenesis of …
The role of microRNAs in development of colitis-associated colorectal cancer
Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel
disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an …
disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an …
Chimeric kinase ALK induces expression of NAMPT and selectively depends on this metabolic enzyme to sustain its own oncogenic function
Q Zhang, J Basappa, HY Wang, S Nunez-Cruz… - Leukemia, 2023 - nature.com
As we show in this study, NAMPT, the key rate-limiting enzyme in the salvage pathway, one
of the three known pathways involved in NAD synthesis, is selectively over-expressed in …
of the three known pathways involved in NAD synthesis, is selectively over-expressed in …
[HTML][HTML] The pathological spectrum of systemic anaplastic large cell lymphoma (ALCL)
IA Montes-Mojarro, J Steinhilber, I Bonzheim… - Cancers, 2018 - mdpi.com
Anaplastic large cell lymphoma (ALCL) represents a group of malignant T-cell
lymphoproliferations that share morphological and immunophenotypical features, namely …
lymphoproliferations that share morphological and immunophenotypical features, namely …
Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas
E Dejean, MH Renalier, M Foisseau, X Agirre… - Leukemia, 2011 - nature.com
The anaplastic lymphoma kinase (ALK), tyrosine kinase oncogene is implicated in a wide
variety of cancers. In this study we used conditional onco-ALK (NPM-ALK and TPM3-ALK) …
variety of cancers. In this study we used conditional onco-ALK (NPM-ALK and TPM3-ALK) …