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Ketamine's mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine's antidepressant effects?
B Quintanilla, CA Zarate Jr, A Pillai - Molecular psychiatry, 2024 - nature.com
Over 300 million people worldwide suffer from major depressive disorder (MDD).
Unfortunately, only 30–40% of patients with MDD achieve complete remission after …
Unfortunately, only 30–40% of patients with MDD achieve complete remission after …
The role of social isolation stress in escalated aggression in rodent models
A Takahashi - Neuroscience Research, 2022 - Elsevier
Anti-social behavior and violence are major public health concerns. Globally, violence
contributes to more than 1.6 million deaths each year. Previous studies have reported that …
contributes to more than 1.6 million deaths each year. Previous studies have reported that …
Neurobiological, behavioral, and cognitive effects of ketamine in adolescents: a review of human and pre-clinical research
J Acevedo, JA Siegel - Behavioural brain research, 2022 - Elsevier
S-ketamine is approved for treatment-resistant patients with depression and adult patients
with suicide behavior. While ketamine is therapeutically beneficial in adults, there is a dearth …
with suicide behavior. While ketamine is therapeutically beneficial in adults, there is a dearth …
Acute MK-801 increases measures of both sign-tracking and goal-tracking in male Sprague-Dawley rats
JM Holden, A Barbaro, K Azure, M Arth - Pharmacology Biochemistry and …, 2024 - Elsevier
Sign-tracking is a Pavlovian conditioned approach behavior thought to be important in
understanding cue-driven relapse to drug use, and strategies for reducing sign-tracking may …
understanding cue-driven relapse to drug use, and strategies for reducing sign-tracking may …
Promises and pitfalls of NMDA receptor antagonists in treating violent aggression
Treatment options for chronically aggressive individuals remain limited despite recent
medical advances. Traditional pharmacological agents used to treat aggression, such as …
medical advances. Traditional pharmacological agents used to treat aggression, such as …
A single dose of ketamine enhances early life stress-induced aggression with no effect on fear memory, anxiety-like behavior, or depression-like behavior in mice.
CJ Bartsch, S Aaflaq, JT Jacobs, M Smith… - Behavioral …, 2023 - psycnet.apa.org
Ketamine is a dissociative anesthetic that has been shown to have antidepressant effects in
humans and has been proposed as a potential treatment for mood disorders such as …
humans and has been proposed as a potential treatment for mood disorders such as …
Acute social defeat during adolescence promotes long-lasting aggression through activation of the medial amygdala
N Mojahed, M Adjei, E Qasem, S Aaflaq… - Frontiers in …, 2024 - frontiersin.org
Traumatic stress, particularly during critical developmental periods such as adolescence,
has been strongly linked to an increased propensity and severity of aggression. Existing …
has been strongly linked to an increased propensity and severity of aggression. Existing …
Visualizing traumatic stress-induced structural plasticity in a medial amygdala pathway using mGRASP
Traumatic stress has been shown to contribute to persistent behavioral changes, yet the
underlying neural pathways are not fully explored. Structural plasticity, a form of long-lasting …
underlying neural pathways are not fully explored. Structural plasticity, a form of long-lasting …
Kétamine et suicidalité: modèles animaux pour comprendre son mécanisme d'action
Résumé Plus des deux tiers des suicides surviennent au cours d'un épisode dépressif
caractérisé. Les mesures de prévention du passage à l'acte et les options thérapeutiques …
caractérisé. Les mesures de prévention du passage à l'acte et les options thérapeutiques …
Medial Amygdala Activity and Circuitry in Socially Stressed Rats
AC Ritger - 2023 - search.proquest.com
Significant social stressors are involved in the development and maintenance of several
neuropsychiatric disorders, many of which also involve alterations in social behavior. The …
neuropsychiatric disorders, many of which also involve alterations in social behavior. The …