Ketamine's mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine's antidepressant effects?

B Quintanilla, CA Zarate Jr, A Pillai - Molecular psychiatry, 2024 - nature.com
Over 300 million people worldwide suffer from major depressive disorder (MDD).
Unfortunately, only 30–40% of patients with MDD achieve complete remission after …

The role of social isolation stress in escalated aggression in rodent models

A Takahashi - Neuroscience Research, 2022 - Elsevier
Anti-social behavior and violence are major public health concerns. Globally, violence
contributes to more than 1.6 million deaths each year. Previous studies have reported that …

Neurobiological, behavioral, and cognitive effects of ketamine in adolescents: a review of human and pre-clinical research

J Acevedo, JA Siegel - Behavioural brain research, 2022 - Elsevier
S-ketamine is approved for treatment-resistant patients with depression and adult patients
with suicide behavior. While ketamine is therapeutically beneficial in adults, there is a dearth …

Acute MK-801 increases measures of both sign-tracking and goal-tracking in male Sprague-Dawley rats

JM Holden, A Barbaro, K Azure, M Arth - Pharmacology Biochemistry and …, 2024 - Elsevier
Sign-tracking is a Pavlovian conditioned approach behavior thought to be important in
understanding cue-driven relapse to drug use, and strategies for reducing sign-tracking may …

Promises and pitfalls of NMDA receptor antagonists in treating violent aggression

CJ Bartsch, JC Nordman - Frontiers in behavioral neuroscience, 2022 - frontiersin.org
Treatment options for chronically aggressive individuals remain limited despite recent
medical advances. Traditional pharmacological agents used to treat aggression, such as …

A single dose of ketamine enhances early life stress-induced aggression with no effect on fear memory, anxiety-like behavior, or depression-like behavior in mice.

CJ Bartsch, S Aaflaq, JT Jacobs, M Smith… - Behavioral …, 2023 - psycnet.apa.org
Ketamine is a dissociative anesthetic that has been shown to have antidepressant effects in
humans and has been proposed as a potential treatment for mood disorders such as …

Acute social defeat during adolescence promotes long-lasting aggression through activation of the medial amygdala

N Mojahed, M Adjei, E Qasem, S Aaflaq… - Frontiers in …, 2024 - frontiersin.org
Traumatic stress, particularly during critical developmental periods such as adolescence,
has been strongly linked to an increased propensity and severity of aggression. Existing …

Visualizing traumatic stress-induced structural plasticity in a medial amygdala pathway using mGRASP

CJ Bartsch, JT Jacobs, N Mojahed, E Qasem… - Frontiers in Molecular …, 2023 - frontiersin.org
Traumatic stress has been shown to contribute to persistent behavioral changes, yet the
underlying neural pathways are not fully explored. Structural plasticity, a form of long-lasting …

Kétamine et suicidalité: modèles animaux pour comprendre son mécanisme d'action

TML Nguyen, F Jollant, L Tritschler, R Colle… - Annales …, 2024 - Elsevier
Résumé Plus des deux tiers des suicides surviennent au cours d'un épisode dépressif
caractérisé. Les mesures de prévention du passage à l'acte et les options thérapeutiques …

Medial Amygdala Activity and Circuitry in Socially Stressed Rats

AC Ritger - 2023 - search.proquest.com
Significant social stressors are involved in the development and maintenance of several
neuropsychiatric disorders, many of which also involve alterations in social behavior. The …