The recent boom in microfluidics and combinatorial indexing strategies, combined with low
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …

Tumorigenesis begins long before the growth of a clinically detectable lesion and, indeed,
even before any of the usual morphological correlates of pre-malignancy are recognizable …

Most cancers in humans are large, measuring centimetres in diameter, and composed of
many billions of cells. An equivalent mass of normal cells would be highly heterogeneous as …

The fight against cancer has drawn researchers from a wide variety of disciplines, ranging
from molecular biology to physics, but the perspective of an ecological theorist has been …

Prostate cancer is a paradigm tumor model for heterogeneity in almost every sense. Its
clinical, spatial, and morphological heterogeneity divided by the high-level molecular …

Biofilms are a major form of microbial life in which cells form dense surface associated
communities that can persist for many generations. The long-life of biofilm communities …

The population of cells that make up a cancer are manifestly heterogeneous at the genetic,
epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra …

Drug gradients are believed to play an important role in the evolution of bacteria resistant to
antibiotics and tumors resistant to anticancer drugs. We use a statistical physics model to …

The genetic and morphological development of colorectal cancer is a paradigm for
tumorigenesis. However, the dynamics of clonal evolution underpinning carcinogenesis …

Via strength in numbers, groups of cells can influence their environments in ways that
individual cells cannot. Large-scale structural patterns and collective functions underpinning …