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RNA modifications: importance in immune cell biology and related diseases
L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …
including generation, transportation, function, and metabolization, they act as critical …
The role of RNA methylation in tumor immunity and its potential in immunotherapy
Y Li, H **, Q Li, L Shi, Y Mao, L Zhao - Molecular cancer, 2024 - Springer
RNA methylation, a prevalent post-transcriptional modification, has garnered considerable
attention in research circles. It exerts regulatory control over diverse biological functions by …
attention in research circles. It exerts regulatory control over diverse biological functions by …
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity
N6-methyladenosine (m6A) is the most prevalent posttranscriptional modification on RNA.
NK cells are the predominant innate lymphoid cells that mediate antiviral and antitumor …
NK cells are the predominant innate lymphoid cells that mediate antiviral and antitumor …
Crosstalk among m6A RNA methylation, hypoxia and metabolic reprogramming in TME: from immunosuppressive microenvironment to clinical application
F Zhang, H Liu, M Duan, G Wang, Z Zhang… - Journal of hematology & …, 2022 - Springer
The tumor microenvironment (TME), which is regulated by intrinsic oncogenic mechanisms
and epigenetic modifications, has become a research hotspot in recent years. Characteristic …
and epigenetic modifications, has become a research hotspot in recent years. Characteristic …
USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis
A Wang, H Huang, JH Shi, X Yu, R Ding, Y Zhang… - The Journal of clinical …, 2023 - jci.org
The functional integrity of Tregs is interwoven with cellular metabolism; however, the
mechanisms governing Treg metabolic programs remain elusive. Here, we identified that the …
mechanisms governing Treg metabolic programs remain elusive. Here, we identified that the …
The emerging role of m6A modification in regulating the immune system and autoimmune diseases
Y Wang, L Li, J Li, B Zhao, G Huang, X Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Over the past several decades, RNA modifications have rapidly emerged as an
indispensable topic in epitranscriptomics. N6-methyladenosine (m6A), namely, methylation …
indispensable topic in epitranscriptomics. N6-methyladenosine (m6A), namely, methylation …
The YTHDF proteins display distinct cellular functions on m6A-modified RNA
YTHDF proteins are main cytoplasmic 'reader'proteins of RNA N 6-methyladenosine (m 6 A)
methylation in mammals. They are largely responsible for m 6 A-mediated regulation in the …
methylation in mammals. They are largely responsible for m 6 A-mediated regulation in the …
Potential roles of N6-methyladenosine (m6A) in immune cells
C Liu, Z Yang, R Li, Y Wu, M Chi, S Gao, X Sun… - Journal of Translational …, 2021 - Springer
Abstract N6-methyl-adenosine (m6A) is one of the most common internal modifications on
RNA molecules present in mammalian cells. Deregulation of m6A modification has been …
RNA molecules present in mammalian cells. Deregulation of m6A modification has been …
Progression of m6A in the tumor microenvironment: hypoxia, immune and metabolic reprogramming
X Han, Y Zhu, J Ke, Y Zhai, M Huang, X Zhang… - Cell Death …, 2024 - nature.com
Abstract Recently, N6-methyladenosine (m6A) has aroused widespread discussion in the
scientific community as a mode of RNA modification. m6A comprises writers, erasers, and …
scientific community as a mode of RNA modification. m6A comprises writers, erasers, and …
Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination
Immunoglobulin heavy chain (IgH) locus-associated G-rich long noncoding RNA (SμGLT) is
important for physiological and pathological B cell DNA recombination. We demonstrate that …
important for physiological and pathological B cell DNA recombination. We demonstrate that …