Neoadjuvant chemotherapy for breast cancer: past, present, and future
Neoadjuvant chemotherapy (NAC) had been developed as a systematic approach before
definitive surgery for the treatment of locally advanced or inoperable breast cancer such as …
definitive surgery for the treatment of locally advanced or inoperable breast cancer such as …
Resistance to CDK4/6 inhibitors in estrogen receptor-positive breast cancer
Estrogen receptor-positive (ER+) breast cancer is the most common form of breast cancer.
Antiestrogens were the first therapy aimed at treating this subtype, but resistance to these …
Antiestrogens were the first therapy aimed at treating this subtype, but resistance to these …
[HTML][HTML] CD8 T cell score as a prognostic biomarker for triple negative breast cancer
CD8 T cell is an essential component of tumor-infiltrating lymphocytes (TIL) and tumor
immune microenvironment (TIME). Using the xCell CD8 T cell score of whole tumor gene …
immune microenvironment (TIME). Using the xCell CD8 T cell score of whole tumor gene …
M1 Macrophage and M1/M2 ratio defined by transcriptomic signatures resemble only part of their conventional clinical characteristics in breast cancer
Tumor associated macrophages (TAMs) play a critical role in biology of various cancers,
including breast cancer. In the current study, we defined “M1” macrophage and “M1”/“M2” …
including breast cancer. In the current study, we defined “M1” macrophage and “M1”/“M2” …
Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on …
S Gao, J Gang, M Yu, G **n, H Tan - BMC cancer, 2021 - Springer
Background Liver cancer is the sixth most commonly diagnosed cancer and the fourth most
common cause of cancer death. The purpose of this work is to find new diagnostic …
common cause of cancer death. The purpose of this work is to find new diagnostic …
[HTML][HTML] MYC targets scores are associated with cancer aggressiveness and poor survival in ER-positive primary and metastatic breast cancer
MYC is one of the most studied oncogenes that is known to promote cell proliferation. We
utilized MYC targets v1 and MYC targets v2 scores of gene set variation analysis and …
utilized MYC targets v1 and MYC targets v2 scores of gene set variation analysis and …
[HTML][HTML] The E2F pathway score as a predictive biomarker of response to neoadjuvant therapy in ER+/HER2− breast cancer
E2F transcription factors play critical roles in the cell cycle. Therefore, their activity is
expected to reflect tumor aggressiveness and responsiveness to therapy. We scored 3905 …
expected to reflect tumor aggressiveness and responsiveness to therapy. We scored 3905 …
Abundance of regulatory T cell (Treg) as a predictive biomarker for neoadjuvant chemotherapy in triple-negative breast cancer
Simple Summary Regulatory CD4+ T cell (Treg) is one of the suppressive immune cells, but
data on its clinical relevance in large human breast cancer cohort is limited. Abundance of …
data on its clinical relevance in large human breast cancer cohort is limited. Abundance of …
[HTML][HTML] Plasmacytoid dendritic cell (pDC) infiltration correlate with tumor infiltrating lymphocytes, cancer immunity, and better survival in triple negative breast cancer …
Simple Summary Dendritic cells (DC) represent a major antigen-presenting cell in the tumor
immune microenvironment (TIME) and play an essential role in cancer immunity. Clinical …
immune microenvironment (TIME) and play an essential role in cancer immunity. Clinical …
[HTML][HTML] Intra-tumoral angiogenesis is associated with inflammation, immune reaction and metastatic recurrence in breast cancer
Angiogenesis is one of the hallmarks of cancer. We hypothesized that intra-tumoral
angiogenesis correlates with inflammation and metastasis in breast cancer patients. To test …
angiogenesis correlates with inflammation and metastasis in breast cancer patients. To test …