Steatotic liver diseases (SLD) are the principal worldwide cause of cirrhosis and end-stage
liver cancer, affecting nearly a quarter of the global population. SLD includes metabolic …

One of the key roles of the immune system is the identification of potentially dangerous
pathogens or tumour cells, and raising a wide range of mechanisms to eliminate them from …

Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to
invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell …

Acute graft-versus-host disease (GVHD) is initially triggered by alloreactive T cells, which
damage peripheral tissues and lymphoid organs. Subsequent transition to chronic GVHD …

Efficacious antitumor vaccines strongly stimulate cancer-specific effector T cells and
counteract the activity of tumor-infiltrating immunosuppressive cells. We hypothesised that …

The success of immunotherapy against infectious diseases has shown us the powerful
potential that such a treatment offers, and substantial work has been done to apply this …

Purpose: T cells influence outcome in follicular lymphoma, but their contributions seem to be
modified by therapy. Their impact in patients receiving rituximab without chemotherapy is …

Ongoing clinical trials explore T cell receptor (TCR) gene therapy as a treatment option for
cancer, but responses in solid tumors are hampered by the immunosuppressive …

Monophosphoryl lipid A (MPLA) is a toll-like receptor 4 ligand that promotes immune
activation in mice and humans, without undesired inflammation. Immunotherapy by the …

Vaccination with dendritic cells (DCs) stimulated with tumor antigens can induce specific
cellular immune response that recognizes a high spectrum of tumor antigens. However, the …