Mechanisms of physiological and pathological cardiac hypertrophy
M Nakamura, J Sadoshima - Nature Reviews Cardiology, 2018 - nature.com
Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …
Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets
The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect
The heart muscle diseases hypertrophic (HCM) and dilated (DCM) cardiomyopathies are
leading causes of sudden death and heart failure in young, otherwise healthy, individuals …
leading causes of sudden death and heart failure in young, otherwise healthy, individuals …
New insights into the role of mTOR signaling in the cardiovascular system
The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular
processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal …
processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal …
Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin
MR Zile, CF Baicu, J S. Ikonomidis, RE Stroud… - Circulation, 2015 - Am Heart Assoc
Background—The purpose of this study was to determine whether patients with heart failure
and a preserved ejection fraction (HFpEF) have an increase in passive myocardial stiffness …
and a preserved ejection fraction (HFpEF) have an increase in passive myocardial stiffness …
Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies
Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in
young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1. 5 …
young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1. 5 …
Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences
Calcium ions are ubiquitous and versatile signaling molecules, capable of decoding a
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways
Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …
population. Both experimental and clinical evidence suggest that diabetic subjects are …
Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation
Rhythmic and effective cardiac contraction depends on appropriately timed generation and
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …