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Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
[HTML][HTML] Mitochondrial dysfunction as a driver of cognitive impairment in Alzheimer's disease
Alzheimer's disease (AD) is the most frequent cause of age-related neurodegeneration and
cognitive impairment, and there are currently no broadly effective therapies. The underlying …
cognitive impairment, and there are currently no broadly effective therapies. The underlying …
[HTML][HTML] Mitochondrial uncoupling, ROS generation and cardioprotection
Mitochondrial oxidative phosphorylation is incompletely coupled, since protons translocated
to the intermembrane space by specific respiratory complexes of the electron transport chain …
to the intermembrane space by specific respiratory complexes of the electron transport chain …
Ischaemia reperfusion injury in liver transplantation: cellular and molecular mechanisms
Liver disease causing end organ failure is a growing cause of mortality. In most cases, the
only therapy is liver transplantation. However, liver transplantation is a complex undertaking …
only therapy is liver transplantation. However, liver transplantation is a complex undertaking …
Redox signaling by reactive electrophiles and oxidants
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
Mitochondrial function in hypoxic ischemic injury and influence of aging
PB Ham III, R Raju - Progress in neurobiology, 2017 - Elsevier
Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …
increases with age leading to dysregulation of molecular pathways linked to mitochondria …
Mitochondria-targeted antioxidants, an innovative class of antioxidant compounds for neurodegenerative diseases: perspectives and limitations
Neurodegenerative diseases comprise a wide spectrum of pathologies characterized by
progressive loss of neuronal functions and structures. Despite having different genetic …
progressive loss of neuronal functions and structures. Despite having different genetic …
Mitochondrial oxidative stress and “mito-inflammation”: actors in the diseases
A decline in mitochondrial redox homeostasis has been associated with the development of
a wide range of inflammatory-related diseases. Continue discoveries demonstrate that …
a wide range of inflammatory-related diseases. Continue discoveries demonstrate that …
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
The worldwide rising prevalence of obesity and insulin resistance is associated with a
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …
Myocardial fatty acid metabolism in health and disease
There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …