Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation
and joint damage. The signaling lymphocytic activation molecule (SLAMF) family of …

Natural killer (NK) cells integrate heterogeneous signals for activation and inhibition using
germline-encoded receptors. These receptors are stochastically co-expressed, and their …

Engineering immune cells to treat hematological malignancies has been a major focus of
research since the first resounding successes of CAR-T-cell therapies in B-ALL. Several …

Background The crossbreeding of specialized beef cattle breeds with Chinese indigenous
cattle is a common method of genetic improvement. **a'nan cattle, a crossbreed of Charolais …

Introduction Pancreatic cancer is a truculent disease with limited treatment options and a
grim prognosis. Immunotherapy has shown promise in treating various types of cancer, but …

SLAM-family receptors promote the progression of hematologic malignancies by regulating
the interaction between malignant cells and the tumor microenvironment. This provides the …

Background Intraductal papillary mucinous neoplasms (IPMNs) are precursors to pancreatic
cancer, but not all IPMNs progress to cancer. The objective of this study was to identify the …

The signaling lymphocytic activation molecule (SLAM) family participates in the modulation
of various innate and adaptive immune responses. SLAM family (SLAMF) receptors include …

Immune cells infiltrating the tumor microenvironment are physiologically important in
controlling cancers. However, emerging studies have shown that cancer cells can evade …

Leukemia is a type of blood cancer characterized by the uncontrolled growth of abnormal
cells in the bone marrow, which replace normal blood cells and disrupt normal blood cell …