[HTML][HTML] Evaluation of intranasal delivery route of drug administration for brain targeting
The acute or chronic drug treatments for different neurodegenerative and psychiatric
disorders are challenging from several aspects. The low bioavailability and limited brain …
disorders are challenging from several aspects. The low bioavailability and limited brain …
Overcoming the blood–brain barrier: the role of nanomaterials in treating neurological diseases
Therapies directed toward the central nervous system remain difficult to translate into
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …
Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
Nanotherapeutics for nose-to-brain drug delivery: an approach to bypass the blood brain barrier
D Lee, T Minko - Pharmaceutics, 2021 - mdpi.com
Treatment of neurodegenerative diseases or other central nervous system (CNS) disorders
has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits …
has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits …
Chitosan and chitosan coating nanoparticles for the treatment of brain disease
S Yu, X Xu, J Feng, M Liu, K Hu - International journal of pharmaceutics, 2019 - Elsevier
Since the application of chitosan magnetic cationic microspheres in brain drug delivery by
Gallo in 1993, chitosan has been extensively studied in brain drug delivery. As the only …
Gallo in 1993, chitosan has been extensively studied in brain drug delivery. As the only …
[HTML][HTML] Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics
Central nervous system (CNS) disorders (eg, multiple sclerosis, Alzheimer's disease, etc.)
represent a growing public health issue, primarily due to the increased life expectancy and …
represent a growing public health issue, primarily due to the increased life expectancy and …
[HTML][HTML] Nanotechnology-based drug delivery for central nervous system disorders
Drug delivery to central nervous system (CNS) diseases is very challenging since the
presence of the innate blood–brain barrier (BBB) and the blood-cerebrospinal fluid barrier …
presence of the innate blood–brain barrier (BBB) and the blood-cerebrospinal fluid barrier …
Chitosan in nasal delivery systems for therapeutic drugs
L Casettari, L Illum - Journal of Controlled Release, 2014 - Elsevier
There is an obvious need for efficient and safe nasal absorption enhancers for the
development of therapeutically efficacious nasal products for small hydrophilic drugs …
development of therapeutically efficacious nasal products for small hydrophilic drugs …
Surface-modified nanocarriers for nose-to-brain delivery: from bioadhesion to targeting
In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating
applications, directly targeting the central nervous system, bypassing the blood brain barrier …
applications, directly targeting the central nervous system, bypassing the blood brain barrier …
Nanotechnology-based drug delivery systems for the treatment of Alzheimer's disease
Alzheimer's disease is a neurological disorder that results in cognitive and behavioral
impairment. Conventional treatment strategies, such as acetylcholinesterase inhibitor drugs …
impairment. Conventional treatment strategies, such as acetylcholinesterase inhibitor drugs …