Sorting out the complexity of SR protein functions
BR Graveley - Rna, 2000 - cambridge.org
Members of the serine/arginine-rich (SR) protein family have multiple functions in the pre-
mRNA splicing reaction. In addition to being required for the removal of constitutively spliced …
mRNA splicing reaction. In addition to being required for the removal of constitutively spliced …
Role of RNA structure in regulating pre-mRNA splicing
MB Warf, JA Berglund - Trends in biochemical sciences, 2010 - cell.com
Pre-mRNA splicing involves removing non-coding introns from RNA transcripts. It is carried
out by the spliceosome, along with other auxiliary factors. In general, research in splicing …
out by the spliceosome, along with other auxiliary factors. In general, research in splicing …
Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells
RNA-based regulation and CRISPR/Cas transcription factors (CRISPR-TFs) have the
potential to be integrated for the tunable modulation of gene networks. A major limitation of …
potential to be integrated for the tunable modulation of gene networks. A major limitation of …
An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.
B Rigat, C Hubert, F Alhenc-Gelas… - The Journal of …, 1990 - Am Soc Clin Investig
A polymorphism consisting of the presence or absence of a 250-bp DNA fragment was
detected within the angiotensin I-converting enzyme gene (ACE) using the endothelial ACE …
detected within the angiotensin I-converting enzyme gene (ACE) using the endothelial ACE …
Prediction of human mRNA donor and acceptor sites from the DNA sequence
Artificial neural networks have been applied to the prediction of splice site location in human
pre-mRNA. A joint prediction scheme where prediction of transition regions between introns …
pre-mRNA. A joint prediction scheme where prediction of transition regions between introns …
ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes
Cells from patients with the UV-sensitive nucleotide excision repair disorder Cockayne's
syndrome (CS) have a specific defect in preferential repair of lesions from the transcribed …
syndrome (CS) have a specific defect in preferential repair of lesions from the transcribed …
Genome-wide discovery of human splicing branchpoints
During the splicing reaction, the 5′ intron end is joined to the branchpoint nucleotide,
selecting the next exon to incorporate into the mature RNA and forming an intron lariat …
selecting the next exon to incorporate into the mature RNA and forming an intron lariat …
[PDF][PDF] Splicing of precursors to mRNAs by the spliceosomes
CB Burge, T Tuschl, PA Sharp - Cold Spring Harbor Monograph Series, 1999 - Citeseer
The splicing of precursors to mRNAs occurs in two steps, both involving single
transesterification reactions (Fig. 1). The first step generates a 2-5 bond at the branch site …
transesterification reactions (Fig. 1). The first step generates a 2-5 bond at the branch site …
Genetic basis of variable exon 9 skip** in cystic fibrosis transmembrane conductance regulator mRNA
CS Chu, BC Trapnell, S Curristin, GR Cutting… - Nature …, 1993 - nature.com
Variable in–frame skip** of exon 9 in cystic fibrosis transmembrane conductance
regulator (CFTR) mRNA transcripts (exon 9−) occurs in the respiratory epithelium. To …
regulator (CFTR) mRNA transcripts (exon 9−) occurs in the respiratory epithelium. To …
Cloning and domain structure of the mammalian splicing factor U2AF
A complementary DNA clone encoding the large subunit of the essential mammalian
premessenger RNA splicing component U2 snRNP auxiliary factor (U2AF65) has been …
premessenger RNA splicing component U2 snRNP auxiliary factor (U2AF65) has been …