Chirality is a key factor in the safety and efficacy of many drug products and thus the
production of single enantiomers of drug intermediates and drugs has become important …

Ene-reductases from the 'Old Yellow Enzyme'family of flavoproteins catalyze the asymmetric
reduction of various α, β-unsaturated compounds at the expense of a nicotinamide cofactor …

Living organisms rely on simultaneous reactions catalysed by mutually compatible and
selective enzymes to synthesize complex natural products and other metabolites. To …

Abstract Flavin‐dependent 'ene'‐reductases (EREDs) are highly selective catalysts for the
asymmetric reduction of activated alkenes. This function is, however, limited to enones …

Insight regarding how diverse enzymatic functions and reactions have evolved from
ancestral scaffolds is fundamental to understanding chemical and evolutionary biology, and …

Flavors and fragrances (F&F) are interesting organic compounds in chemistry. These
compounds are widely used in the food, cosmetic, and medical industries. Enzymatic …

The selective conversion of mixtures of Z/E alkenes into chiral products is a synthetic
challenge. Biocatalytic strategies can transform isomeric alkenes into stereopure …

A novel chiral bisphosphine-thiourea ligand was developed and applied in the highly
enantioselective hydrogenation of β, β-disubstituted nitroalkenes (up to 99% yield and 99 …

Enantioselective reduction reactions are privileged transformations for the construction of
trisubstituted stereogenic centers. While these include established synthetic strategies, such …

Ene-reductases (EREDs) catalyze the reduction of electron-deficient C═ C bonds. Herein,
we report the first example of ERED-catalyzed net reduction of C═ C bonds of enimines (α …