The energetic and allosteric landscape for KRAS inhibition
Thousands of proteins have been validated genetically as therapeutic targets for human
diseases. However, very few have been successfully targeted, and many are considered …
diseases. However, very few have been successfully targeted, and many are considered …
Molecular basis of RanGTP-activated release of Histones H2A-H2B from Importin-9
Imp9 is the primary importin for shuttling H2A-H2B from the cytoplasm to the nucleus. It
employs an unusual mechanism where the binding of RanGTP is insufficient to release H2A …
employs an unusual mechanism where the binding of RanGTP is insufficient to release H2A …
Functional protein oligomers
S Sahoo, LR Balireddygari, AA Padhy, S Kumari… - The Three Functional …, 2025 - Elsevier
Protein oligomerization is a fundamental, yet a complex process adapted by the cell to
evolve proteins with diverse or efficient functions and enhanced stability. This evolutionary …
evolve proteins with diverse or efficient functions and enhanced stability. This evolutionary …