The entry of anti-infectives into the central nervous system (CNS) depends on the
compartment studied, molecular size, electric charge, lipophilicity, plasma protein binding …

Cationic antimicrobial peptides are produced by almost all species of life as a component of
their immediate non-specific defense against infections. The assets of these peptides in …

To clarify whether apoptosis is involved in the injury processes induced by autoantibody
against cardiac β1-adrenoceptor, we investigated the biological and apoptotic effects of …

Pneumococcal meningitis continues to be associated with high rates of mortality and long-
term neurological sequelae. The most common route of infection starts by nasopharyngeal …

La creciente tasa de resistencia de Staphylococcus aureus a meticilina (SARM) observada
en la década de los años 90, generó importantes lineas de estudio de nuevos antibióticos …

Infections caused by drug-resistant pathogens are on the rise. Daptomycin, a cyclic
lipopeptide with activity against most Gram-positive pathogens, including vancomycin …

Over the last decade, methicillin-resistant Staphylococcus aureus (MRSA) strains have
emerged as serious pathogens. These strains are often multiresistant to several antibiotic …

The lipopeptide daptomycin has been approved for use in skin and skin-structure infections
but has failed to meet statistical noninferiority criteria in a clinical trial for severe community …

Covering: 1953 to September 2005Daptomycin (Cubicin®) is a lipopeptide antibiotic
approved in the USA in 2003 for the treatment of skin and skin structure infections caused by …

Spurred by advancements in microbial genetics and enzyme engineering, chemoenzymatic
strategies, which combine enzymatic and synthetic transformations, have increasingly made …