Cholangiocarcinoma

PJ Brindley, M Bachini, SI Ilyas, SA Khan… - Nature reviews Disease …, 2021 - nature.com
Cholangiocarcinoma (CCA) is a highly lethal adenocarcinoma of the hepatobiliary system,
which can be classified as intrahepatic, perihilar and distal. Each anatomic subtype has …

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Z Zhang, H Tang, P Chen, H **e, Y Tao - Signal transduction and …, 2019 - nature.com
The trillions of microorganisms in the gut microbiome have attracted much attention recently
owing to their sophisticated and widespread impacts on numerous aspects of host …

JAK/STAT signaling: molecular targets, therapeutic opportunities, and limitations of targeted inhibitions in solid malignancies

B Rah, RA Rather, GR Bhat, AB Baba… - Frontiers in …, 2022 - frontiersin.org
JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the
myriad of cellular processes initiated by various types of ligands such as growth factors …

The toxicity of metallic nanoparticles on liver: the subcellular damages, mechanisms, and outcomes

Y Yao, Y Zang, J Qu, M Tang… - International journal of …, 2019 - Taylor & Francis
Metallic nanoparticles (MNPs) are new engineering materials with broad prospects for
biomedical applications; thus, their biosafety has drawn great concern. The liver is the main …

The role of autophagy in liver cancer: crosstalk in signaling pathways and potential therapeutic targets

J Cui, HM Shen, LHK Lim - Pharmaceuticals, 2020 - mdpi.com
Autophagy is an evolutionarily conserved lysosomal-dependent pathway for degrading
cytoplasmic proteins, macromolecules, and organelles. Autophagy-related genes (Atgs) are …

[HTML][HTML] PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era

CJ Li, LT Lin, MF Hou, PY Chu - Oncology Reports, 2021 - spandidos-publications.com
Breast cancer is a common malignant tumor in women. Triple‑negative breast cancer
(TNBC) is highly invasive with a high rate of metastasis and poor prognosis. Programmed …

[HTML][HTML] Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update

GO Elpek - World Journal of Clinical Cases, 2021 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common type of cancer among primary
malignant tumors of the liver and is a consequential cause of cancer-related deaths …

DNA methylation in cell plasticity and malignant transformation in liver diseases

M Kim, E Delgado, S Ko - Pharmacology & therapeutics, 2023 - Elsevier
The liver possesses extraordinary regenerative capacity mainly attributable to the ability of
hepatocytes (HCs) and biliary epithelial cells (BECs) to self-replicate. This ability is left over …

The role and impact of viruses on cancer development

A Contreras, SA Sánchez… - Periodontology …, 2024 - Wiley Online Library
This review focuses on three major aspects of oncoviruses' role in cancer development. To
begin, we discuss their geographic distribution, revealing that seven oncoviruses cause …

Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma

M Han, Z Liao, F Liu, X Chen, B Zhang - Biomarker research, 2020 - Springer
Hepatocellular carcinoma (HCC) is a type of liver cancer with poor prognosis. There have
been demonstrated to exist many possible mechanisms in HCC tumorigenesis, and recent …