Background Mild cognitive impairment (MCI) depicts a transitory phase between healthy
elderly and the onset of Alzheimer's disease (AD) with worsening cognitive impairment …

Alzheimer's disease (AD) is a progressive neurodegenerative disease. Although it has been
studied for years, the pathogenesis of AD is still controversial. Genetic factors may play an …

Background: Functional imaging methods, such as resting-state functional magnetic
resonance imaging, reflect changes in neural connectivity and may help to assess the …

Understanding the role of Tau protein aggregation in the pathogenesis of Alzheimer's
disease is critical for the development of new Tau-based therapeutic strategies to slow or …

Functional magnetic resonance imaging (fMRI) studies have suggested that advanced age
may mediate the effects of transcranial direct current stimulation (tDCS) on brain function …

Background Functional magnetic resonance imaging (fMRI) is an MRI-based neuroimaging
technique that measures brain activity on the basis of blood oxygenation level. This study …

Neurodegeneration, characterized by gradual and selective spreading of pathologic
changes in a target brain network, leads to specific behavioral and cognitive dysfunctions …

This systematic review examines the genetic and epigenetic factors associated with resting-
state functional connectivity (RSFC) in healthy human adult brains across the lifespan, with a …

Alzheimer's disease (AD) has a long neuropathological accumulation phase before the
onset of dementia. Such AD neuropathological deposition between neurons impairs the …

Background APOE ε4 allele is most common genetic risk factor for Alzheimer's disease (AD)
and cognitive decline. However, it remains poorly understood why only some carriers of …