Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically
manifests in midlife with motor, cognitive, and/or psychiatric symptoms. The disease is …

Glial cells play critical roles in the normal development and function of neural circuits, but in
many neurodegenerative diseases, they become dysregulated and may contribute to the …

Huntington disease (HD) is an inherited neurodegenerative disorder caused by an
expansion of the CAG repeat region in the first exon of the huntingtin gene …

Neuroplasticity accounts for the ability of the brain to change in both structure and function in
consequence of life experiences. An enhanced stimulation provided by the environment is …

Background Huntington's disease (HD) starts its pathology long before clinical
manifestation, however, there is no therapy to cure it completely and only a few studies have …

Lifelong cognitive engagement conveys benefits in Huntington's disease (HD) and may
positively affect non-cognitive domains in other populations. However, the effect of lifelong …

Cell signaling is central to neuronal activity and its dysregulation may lead to
neurodegeneration and cognitive decline. Here, we show that selective genetic potentiation …

While Huntington disease (HD) is caused solely by a polyglutamine expansion in the
huntingtin gene, environmental factors can influence HD onset and progression. Here, we …

The 'reserve'hypothesis posits that the brain undergoes structural and functional
reorganisation to actively cope with brain damage or disease. Consistent with passive and …