Protein tyrosine phosphatases in the human genome
Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by
90 genes in the human genome. Here, we present the set of 107 genes in the human …
90 genes in the human genome. Here, we present the set of 107 genes in the human …
Protein tyrosine phosphatases and the immune response
T Mustelin, T Vang, N Bottini - Nature Reviews Immunology, 2005 - nature.com
Reversible tyrosine phosphorylation of proteins is a key regulatory mechanism for numerous
important aspects of eukaryotic physiology and is catalysed by kinases and phosphatases …
important aspects of eukaryotic physiology and is catalysed by kinases and phosphatases …
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
We report that a single-nucleotide polymorphism (SNP) in the gene (PTPN22) encoding the
lymphoid protein tyrosine phosphatase (LYP), a suppressor of T-cell activation, is associated …
lymphoid protein tyrosine phosphatase (LYP), a suppressor of T-cell activation, is associated …
Nucleus alignment and cell signaling in fibroblasts: response to a micro-grooved topography
Cellular response to scaffold materials is of great importance in cellular and tissue
engineering, and it is perhaps the initial cell contact with the scaffold that determines …
engineering, and it is perhaps the initial cell contact with the scaffold that determines …
Positive and negative regulation of T-cell activation through kinases and phosphatases
The sequence of events in T-cell antigen receptor (TCR) signalling leading to T-cell
activation involves regulation of a number of protein tyrosine kinases (PTKs) and the …
activation involves regulation of a number of protein tyrosine kinases (PTKs) and the …
Chemical proteomics and its application to drug discovery
DA Jeffery, M Bogyo - Current opinion in biotechnology, 2003 - Elsevier
The completion of the human genome sequencing project has provided a flood of new
information that is likely to change the way scientists approach the study of complex …
information that is likely to change the way scientists approach the study of complex …
Protein-tyrosine phosphatase 1B substrates and metabolic regulation
Metabolic homeostasis requires integration of complex signaling networks which, when
deregulated, contribute to metabolic syndrome and related disorders. Protein-tyrosine …
deregulated, contribute to metabolic syndrome and related disorders. Protein-tyrosine …
Classification and functional annotation of eukaryotic protein kinases
Reversible protein phosphorylation by protein kinases and phosphatases is a ubiquitous
signaling mechanism in all eukaryotic cells. A multilevel hidden Markov model library is …
signaling mechanism in all eukaryotic cells. A multilevel hidden Markov model library is …
A requirement for sustained ERK signaling during thymocyte positive selection in vivo
LK McNeil, TK Starr… - Proceedings of the …, 2005 - National Acad Sciences
It is unknown how the contrasting events of positive and negative selection can lead to the
distinct biological outcomes of life or death. An increasing body of evidence suggests that …
distinct biological outcomes of life or death. An increasing body of evidence suggests that …
T cell receptor stimulation, reactive oxygen species, and cell signaling
MS Williams, J Kwon - Free Radical Biology and Medicine, 2004 - Elsevier
In the immune system, much of the focus on reactive oxygen species (ROS) has been
regarding their role in antimicrobial defense as part of the innate immune system. In addition …
regarding their role in antimicrobial defense as part of the innate immune system. In addition …