Mechanisms and regulation of substrate degradation by the 26S proteasome
The 26S proteasome is involved in degrading and regulating the majority of proteins in
eukaryotic cells, which requires a sophisticated balance of specificity and promiscuity. In this …
eukaryotic cells, which requires a sophisticated balance of specificity and promiscuity. In this …
[HTML][HTML] Regulation of proteasome activity in health and disease
M Schmidt, D Finley - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2014 - Elsevier
The ubiquitin–proteasome system (UPS) is the primary selective degradation system in the
nuclei and cytoplasm of eukaryotic cells, required for the turnover of myriad soluble proteins …
nuclei and cytoplasm of eukaryotic cells, required for the turnover of myriad soluble proteins …
Oxidative stress-mediated regulation of proteasome complexes
CT Aiken, RM Kaake, X Wang, L Huang - Molecular & Cellular Proteomics, 2011 - ASBMB
Oxidative stress has been implicated in aging and many human diseases, notably
neurodegenerative disorders and various cancers. The reactive oxygen species that are …
neurodegenerative disorders and various cancers. The reactive oxygen species that are …
Ubiquitin and ubiquitin-like proteins in protein regulation
J Herrmann, LO Lerman, A Lerman - Circulation research, 2007 - Am Heart Assoc
The discovery of the ubiquitin system was awarded with the Nobel Prize in Chemistry in
2004. Labeling of intracellular proteins for degradation by a multienzymatic complex, called …
2004. Labeling of intracellular proteins for degradation by a multienzymatic complex, called …
Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules
B Guillaume, J Chapiro, V Stroobant… - Proceedings of the …, 2010 - National Acad Sciences
Most antigenic peptides presented by MHC class I molecules result from the degradation of
intracellular proteins by the proteasome. In lymphoid tissues and cells exposed to IFNγ, the …
intracellular proteins by the proteasome. In lymphoid tissues and cells exposed to IFNγ, the …
Ubiquitin proteasome dysfunction in human hypertrophic and dilated cardiomyopathies
JM Predmore, P Wang, F Davis, S Bartolone… - Circulation, 2010 - Am Heart Assoc
Background—The ubiquitin proteasome system maintains a dynamic equilibrium of proteins
and prevents accumulation of damaged and misfolded proteins, yet its role in human cardiac …
and prevents accumulation of damaged and misfolded proteins, yet its role in human cardiac …
Treatment targets for right ventricular dysfunction in pulmonary arterial hypertension
Right ventricle (RV) dysfunction is the strongest predictor of mortality in pulmonary arterial
hypertension (PAH), but, at present, there are no therapies directly targeting the failing RV …
hypertension (PAH), but, at present, there are no therapies directly targeting the failing RV …
Mass spectrometric characterization of the affinity-purified human 26S proteasome complex
The 26S proteasome is a multisubunit complex responsible for degradation of ubiquitinated
substrates, which plays a critical role in regulating various biological processes. To fully …
substrates, which plays a critical role in regulating various biological processes. To fully …
Relationship between amyloid-beta and the ubiquitin–proteasome system in Alzheimer's disease
L Hong, HC Huang, ZF Jiang - Neurological research, 2014 - Taylor & Francis
Amyloid-beta (Abeta) peptide is the original causative factor of Alzheimer's disease (AD)
according to the amyloid cascade hypothesis. The ubiquitin–proteasome system (UPS), the …
according to the amyloid cascade hypothesis. The ubiquitin–proteasome system (UPS), the …
Regulation of proteasome activity by (post-) transcriptional mechanisms
Intracellular protein synthesis, folding, and degradation are tightly controlled processes to
ensure proper protein homeostasis. The proteasome is responsible for the degradation of …
ensure proper protein homeostasis. The proteasome is responsible for the degradation of …