Diabetic kidney disease (DKD) is a long-term and serious complication of diabetes that
affects millions of people worldwide. It is characterized by proteinuria, glomerular damage …

In 1981, de Bold and his colleagues made the seminal observation that infusion of extracts
of atrial tissue into rats caused a copious natriuresis. 1 This then led to the isolation and …

Background In the present study, we aimed to determine the frequency of a significant
reduction in urinary albumin excretion and factors affecting such reduction in patients with …

Molecular mechanisms of diabetic renal hypertrophy. Altered growth of renal cells is one of
the early abnormalities detected after the onset of diabetes. Cell culture studies whereby …

Stockand, James D., and Steven C. Sansom. Glomerular Mesangial Cells: Electrophysiology
and Regulation of Contraction. Physiol. Rev. 78: 723–744, 1998.—Mesangial cells are …

Thiazolidinedione (TZD) compounds are widely used as oral hypoglycemic agents. Herein,
we provide evidence showing that troglitazone, one of the TZD compounds, is able to …

Despite current practice, patients with chronic kidney disease (CKD) are at increased risk of
progression to end-stage renal disease and cardiovascular events. Neprilysin inhibition …

In the modern scientific landscape, natriuretic peptides are a complex and interesting
network of molecules playing pleiotropic effects on many organs and tissues, ensuring the …

Plasma volume, the intravascular portion of the extracellular fluid volume, can be measured
using standard dilution techniques with radiolabeled tracer molecules. In healthy persons …

Sepsis, the most serious complication of infection, occurs when a cascade of potentially life-
threatening inflammatory responses is triggered. Potentially life-threatening septic shock is a …