Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Interest in cardioimmunology has reached new heights as the experimental cardiology field
works to tap the unrealized potential of immunotherapy for clinical care. Within this space is …

Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …

There is a large body of evidence that cellular metabolism governs inflammation, and that
inflammation contributes to the progression of atherosclerosis. However, whether …

Macrophages sense changes in the extracellular matrix environment through the integrins
and play a central role in regulation of the reparative response after myocardial infarction …

Chemotherapy prior to immune checkpoint blockade (ICB) treatment appears to improve ICB
efficacy but resistance to ICB remains a clinical challenge and is attributed to highly plastic …

The increasing use of single-cell immune profiling and advanced microscopic imaging
technologies has deepened our understanding of the cardiac immune system, confirming …

Macrophages are present in almost all organs. Apart from being immune sentinels, tissue-
resident macrophages (TRMs) have organ-specific functions that require a specialized …

Immune cell function among the myocardium, now more than ever, is appreciated to
regulate cardiac function and pathophysiology. This is the case for both innate immunity …