The novel betacoronavirus, SARS-CoV-2 (severe acute respiratory syndrome coronavirus
2), has spread across the globe at an unprecedented rate since its first emergence in Wuhan …

Vaccine development against SARS-CoV-2 has been fierce due to the devastating COVID-
19 pandemic and has included all potential approaches for providing the global community …

Emergence of SARS-CoV-2 variants of concern (VOCs), including the highly transmissible
Omicron and Delta strains, has posed constant challenges to the current COVID-19 vaccines …

The ongoing SARS-CoV-2 pandemic has led to the focused application of resources and
scientific expertise toward the goal of develo** investigational vaccines to prevent COVID …

Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) has emerged as
the infectious agent causing the pandemic coronavirus disease 2019 (COVID-19) with …

Although one member of the poxvirus family, variola virus, has caused one of the most
devastating human infections worldwide, smallpox, the knowledge gained over the last 30 …

Background COH04S1, a synthetic attenuated modified vaccinia virus Ankara vector co-
expressing SARS-CoV-2 spike and nucleocapsid antigens, was tested for safety and …

Lumpy skin disease virus (LSDV) is a member of the Capripoxvirus genus, mainly infecting
cattle and buffalo, which until relatively recently was only endemic in parts of Africa and then …

Antigen-specific tissue-resident memory T cells (Trms) and neutralizing IgA antibodies
provide the most effective protection of the lungs from viral infections. To induce those …

Second-generation COVID-19 vaccines could contribute to establish protective immunity
against SARS-CoV-2 and its emerging variants. We developed COH04S1, a synthetic …