The field of fluorogenic RNA aptamers is a burgeoning research area that aims to address
the lack of naturally fluorescent RNA molecules for RNA detection and imaging. These small …

The ability to simultaneously image the spatiotemporal activity signatures from many
neurons during unrestrained vertebrate behaviors has become possible through the …

Optical interrogation of voltage in deep brain locations with cellular resolution would be
immensely useful for understanding how neuronal circuits process information. Here, we …

Dendritic spines mediate most excitatory neurotransmission in the nervous system, so their
function must be critical for the brain. Spines are biochemical compartments but might also …

A central goal in neuroscience is to determine how the brain's neuronal circuits generate
perception, cognition and emotions and how these lead to appropriate behavioural actions …

Monitoring spiking activity across large neuronal populations at behaviorally relevant
timescales is critical for understanding neural circuit function. Unlike calcium imaging …

The ability to optically image cellular transmembrane voltages at millisecond-timescale
resolutions can offer unprecedented insight into the function of living brains in behaving …

Understanding how neuronal activity patterns in the brain correlate with complex behavior is
one of the primary goals of modern neuroscience. Chemical transmission is the major way of …

Various implementations of mesoscopes provide optical access for calcium imaging across
multi-millimeter fields of view in the mammalian brain; however, capturing the activity of the …

As a “holy grail” of neuroscience, optical imaging of membrane potential could enable high
resolution measurements of spiking and synaptic activity in neuronal populations. This has …