Digital histopathology by infrared spectroscopic imaging

R Bhargava - Annual Review of Analytical Chemistry, 2023 - annualreviews.org
Infrared (IR) spectroscopic imaging records spatially resolved molecular vibrational spectra,
enabling a comprehensive measurement of the chemical makeup and heterogeneity of …

Understanding the patterns that neural networks learn from chemical spectra

LH Rieger, M Wilson, T Vegge, E Flores - Digital Discovery, 2023 - pubs.rsc.org
Analysing spectra from experimental characterization of materials is time consuming,
susceptible to distortions in data, requires specific domain knowledge, and may be …

Phasor Representation Approach for Rapid Exploratory Analysis of Large Infrared Spectroscopic Imaging Data Sets

SS Mukherjee, R Bhargava - Analytical chemistry, 2023 - ACS Publications
Infrared (IR) spectroscopic imaging is potentially useful for digital histopathology as it
provides spatially resolved molecular absorption spectra, which can subsequently yield …

Classification of colorectal primer carcinoma from normal colon with mid‐infrared spectra

B Borkovits, E Kontsek, A Pesti, P Gordon… - Journal of …, 2024 - Wiley Online Library
In this project, we used formalin‐fixed paraffin‐embedded (FFPE) tissue samples to
measure thousands of spectra per tissue core with Fourier transform mid‐infrared …

Comprehensive Histopathology Imaging in Pancreatic Biopsies: High Definition Infrared Imaging with Machine Learning Approach

D Liberda, P Koziol, TP Wrobel - International Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Infrared (IR) based histopathology offers a new paradigm in looking at tissues and can
provide a complimentary information source for more classical histopathology, which makes …

Statistical considerations and tools to improve histopathologic protocols with spectroscopic imaging

S Mittal, J Kim, R Bhargava - Applied spectroscopy, 2022 - journals.sagepub.com
Advances in infrared (IR) spectroscopic imaging instrumentation and data science now
present unique opportunities for large validation studies of the concept of histopathology …

Metal carbonyl loaded nanoparticles for breast cancer biomarker detection

C Richard, PH Hsieh, M Confer… - … Imaging, Sensing, and …, 2024 - spiedigitallibrary.org
The potential advantages of infrared spectroscopic imaging for examination of cells and
tissue biopsies for cancer histopathology is high, however there are fundamental limitations …

Weakly supervised anomaly detection coupled with Fourier transform infrared (FT-IR) spectroscopy for the identification of non-normal tissue

D Ferguson, A Henderson, EF McInnes, P Gardner - Analyst, 2023 - pubs.rsc.org
The detection and classification of histopathological abnormal tissue constituents using
machine learning (ML) techniques generally requires example data for each tissue or cell …