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Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5
M Hrubša, T Siatka, I Nejmanová, M Vopršalová… - Nutrients, 2022 - mdpi.com
This review summarizes the current knowledge on essential vitamins B1, B2, B3, and B5.
These B-complex vitamins must be taken from diet, with the exception of vitamin B3, that can …
These B-complex vitamins must be taken from diet, with the exception of vitamin B3, that can …
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD
risk remains even for individuals receiving all guideline-recommended interventions. Niacin …
risk remains even for individuals receiving all guideline-recommended interventions. Niacin …
Biochemical and clinical impact of organic uremic retention solutes: a comprehensive update
R Vanholder, A Pletinck, E Schepers, G Glorieux - Toxins, 2018 - mdpi.com
In this narrative review, the biological/biochemical impact (toxicity) of a large array of known
individual uremic retention solutes and groups of solutes is summarized. We classified these …
individual uremic retention solutes and groups of solutes is summarized. We classified these …
The Plasma NAD+ Metabolome Is Dysregulated in “Normal” Aging
Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that serves as
an electron carrier in cellular metabolism and plays a crucial role in the maintenance of …
an electron carrier in cellular metabolism and plays a crucial role in the maintenance of …
Possible adverse effects of high-dose nicotinamide: mechanisms and safety assessment
ES Hwang, SB Song - Biomolecules, 2020 - mdpi.com
Nicotinamide (NAM) at doses far above those recommended for vitamins is suggested to be
effective against a wide spectrum of diseases and conditions, including neurological …
effective against a wide spectrum of diseases and conditions, including neurological …
The significance of NAD+ metabolites and nicotinamide N-methyltransferase in chronic kidney disease
R Takahashi, T Kanda, M Komatsu, T Itoh… - Scientific reports, 2022 - nature.com
Dysregulation of nicotinamide adenine dinucleotide (NAD+) metabolism contributes to the
initiation and progression of age-associated diseases, including chronic kidney disease …
initiation and progression of age-associated diseases, including chronic kidney disease …
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis
N Braidy, Y Liu - Experimental Gerontology, 2020 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is
present in all living cells. NAD+ acts as an important cofactor and substrate for a multitude of …
present in all living cells. NAD+ acts as an important cofactor and substrate for a multitude of …
Roles of NAD+ in Acute and Chronic Kidney Diseases
Nicotinamide adenine dinucleotide (oxidized form, NAD+) is a critical coenzyme, with
functions ranging from redox reactions and energy metabolism in mitochondrial respiration …
functions ranging from redox reactions and energy metabolism in mitochondrial respiration …
The chemistry of the vitamin B3 metabolome
The functional cofactors derived from vitamin B3 are nicotinamide adenine dinucleotide
(NAD+), its phosphorylated form, nicotinamide adenine dinucleotide phosphate (NADP+) …
(NAD+), its phosphorylated form, nicotinamide adenine dinucleotide phosphate (NADP+) …