Regulation of and challenges in targeting NAD+ metabolism

ME Migaud, M Ziegler, JA Baur - Nature Reviews Molecular Cell …, 2024 - nature.com
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …

Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5

M Hrubša, T Siatka, I Nejmanová, M Vopršalová… - Nutrients, 2022 - mdpi.com
This review summarizes the current knowledge on essential vitamins B1, B2, B3, and B5.
These B-complex vitamins must be taken from diet, with the exception of vitamin B3, that can …

A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk

M Ferrell, Z Wang, JT Anderson, XS Li, M Witkowski… - Nature Medicine, 2024 - nature.com
Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD
risk remains even for individuals receiving all guideline-recommended interventions. Niacin …

Biochemical and clinical impact of organic uremic retention solutes: a comprehensive update

R Vanholder, A Pletinck, E Schepers, G Glorieux - Toxins, 2018 - mdpi.com
In this narrative review, the biological/biochemical impact (toxicity) of a large array of known
individual uremic retention solutes and groups of solutes is summarized. We classified these …

The Plasma NAD+ Metabolome Is Dysregulated in “Normal” Aging

J Clement, M Wong, A Poljak, P Sachdev… - Rejuvenation …, 2019 - liebertpub.com
Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that serves as
an electron carrier in cellular metabolism and plays a crucial role in the maintenance of …

Possible adverse effects of high-dose nicotinamide: mechanisms and safety assessment

ES Hwang, SB Song - Biomolecules, 2020 - mdpi.com
Nicotinamide (NAM) at doses far above those recommended for vitamins is suggested to be
effective against a wide spectrum of diseases and conditions, including neurological …

The significance of NAD+ metabolites and nicotinamide N-methyltransferase in chronic kidney disease

R Takahashi, T Kanda, M Komatsu, T Itoh… - Scientific reports, 2022 - nature.com
Dysregulation of nicotinamide adenine dinucleotide (NAD+) metabolism contributes to the
initiation and progression of age-associated diseases, including chronic kidney disease …

NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis

N Braidy, Y Liu - Experimental Gerontology, 2020 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is
present in all living cells. NAD+ acts as an important cofactor and substrate for a multitude of …

Roles of NAD+ in Acute and Chronic Kidney Diseases

M Morevati, EF Fang, ML Mace, M Kanbay… - International journal of …, 2022 - mdpi.com
Nicotinamide adenine dinucleotide (oxidized form, NAD+) is a critical coenzyme, with
functions ranging from redox reactions and energy metabolism in mitochondrial respiration …

The chemistry of the vitamin B3 metabolome

MV Makarov, SAJ Trammell… - Biochemical Society …, 2019 - portlandpress.com
The functional cofactors derived from vitamin B3 are nicotinamide adenine dinucleotide
(NAD+), its phosphorylated form, nicotinamide adenine dinucleotide phosphate (NADP+) …