Chromatin consists of a complex of DNA and histone proteins as its core components and
plays an important role in both packaging DNA and regulating DNA metabolic pathways …

DNA methylation plays a critical role in the regulation of chromatin structure and gene
expression and is involved in a variety of biological processes. The levels and patterns of …

Facioscapulohumeral dystrophy (FSHD) is associated with somatic chromatin relaxation of
the D4Z4 repeat array and derepression of the D4Z4-encoded DUX4 retrogene coding for a …

The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

Inborn errors of immunity (IEIs) consist of numerous rare, inherited defects of the immune
system that affect about 500,000 people in the United States. As advancements in diagnosis …

DNA methylation plays an important role in the maintenance of genomic stability. Ten-
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …

Telomere biology disorders are a complex set of illnesses defined by the presence of very
short telomeres. Individuals with classic dyskeratosis congenita have the most severe …

Abstract The life-threatening Immunodeficiency, Centromeric Instability and Facial
Anomalies (ICF) syndrome is a genetically heterogeneous autosomal recessive disorder …

Facioscapulohumeral dystrophy (FSHD) is an autosomal dominant muscular dystrophy in
which no mutation of pathogenic gene (s) has been identified. Instead, the disease is, in …

Telomeres and adjacent subtelomeric regions are packaged as heterochromatin in many
organisms. The heterochromatic features include DNA methylation, histones H3-Lys9 …