Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

The bone remodelling cycle (see Poster panel “The bone remodelling cycle”) maintains the
integrity of the skeleton through the balanced activities of its constituent cell types. These are …

This review describes the key discoveries over the last 15 years that have led to a clearer
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …

As Americans live longer, degenerative skeletal diseases, such as osteoporosis, become
increasingly prevalent. Regardless of cause, osteoporosis reflects a relative enhancement of …

Osteoclasts, the sole bone‐resorbing cells, arise by fusion and differentiation of monocyte/
macrophage precursors. Matrix degradation requires adhesion of the osteoclast to bone, an …

Nitrogen-containing bisphosphonates (nBPs) are bone-specific agents that inhibit farnesyl
diphosphate synthase. nBPs' strong affinity for bone, and not for other tissues, makes them …

Chronic inflammation during many diseases is associated with bone loss. While interferons
(IFNs) are often inhibitory to osteoclast formation, the complex role that IFN and interferon …

Bone resorption is an important cellular function in skeletal development and remodeling of
the adult skeleton. Most of the pathological bone disease conditions like osteoporosis reflect …

The vacuolar-type H+-ATPase (V-ATPase) proton pump is a macromolecular complex
composed of at least 14 subunits organized into two functional domains, V1 and V0. The …

The secretion of cytokines by immune cells plays a significant role in determining the course
of an inflammatory response. The levels and timing of each cytokine released are critical for …