Historically, natural products have been used since ancient times and in folklore for the
treatment of many diseases and illnesses. Classical natural product chemistry …

Filamentous fungi are unique organisms—rivaled only by actinomycetes and plants—in
producing a wide range of natural products called secondary metabolites. These …

The simplistic image of the bacterium as an isolated, planktonic, self-cloning automaton is
refuted. We now recognize bacteria as microorganisms of enormous diversity and …

Secondary metabolites play a pivotal role in the antagonistic activities of some biocontrol
species of Trichoderma resulting in the suppression of plant pathogens, but their …

Mycobacterium ulcerans is the causative agent of Buruli ulcer, a severe human skin disease
that occurs primarily in Africa and Australia. Infection with M. ulcerans results in persistent …

The rifamycins1 belong to the family of ansamycin antibiotics, 3, 4 so named because of
their basket-like molecular architecture comprising an aromatic moiety bridged at …

Secondary metabolites profoundly affect microbial physiology, metabolism and stress
responses. Increasing evidence suggests that these molecules can modulate microbial …

During 1914 to 1939, Selman A. Waksman had been consistently systematically screening
soil bacteria and fungi to find an antibiotic for tuberculosis. In 1939, he discovers the effect of …

Terpenoids are the largest, most diverse class of plant natural products and they play
numerous functional roles in primary metabolism and in ecological interactions. The first …

A last line of defence against “superbugs” are the vancomycin group antibiotics. This review
describes the determination of their mode of action, and a mechanism of resistance to them …