CRISPR/Cas9-mediated cleavage of DNA, which depends on the endonuclease activity of
Cas9, has been widely used for gene editing due to its excellent programmability and …

The CRISPR/Cas9 system is a powerful tool for genome editing, utilizing the Cas9 nuclease
and programmable single guide RNA (sgRNA). However, the Cas9 nuclease activity can be …

CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-
associated proteins) has undergone marked advancements since its discovery as an …

Multidrug resistance in bacterial strains known as superbugs is estimated to cause fatal
infections worldwide. Migration and urbanization have resulted in overcrowding and …

Goat milk provides benefits to human health due to its richness in bioactive components,
such as polyunsaturated fatty acids (PUFAs). The fatty acid desaturase 2 (FADS2) is the first …

Axonal spheroids (dystrophic neurites) are commonly found around amyloid deposits in
Alzheimer's disease (AD). They impair electrical conduction, disrupt neural circuits, and …

Alcohol use disorder (AUD) is a chronic, relapsing brain disease associated with a myriad of
debilitating consequences. Unfortunately, current therapies are limited, and the etiology is …

Recent genomics studies revealed that long noncoding RNAs (lncRNAs) are equally
abundant as protein coding genes in the human genome, and they are thought to regulate …