The initiation of eukaryotic DNA replication
DNA replication in eukaryotic cells initiates from large numbers of sites called replication
origins. Initiation of replication from these origins must be tightly controlled to ensure the …
origins. Initiation of replication from these origins must be tightly controlled to ensure the …
DNA replication and oncogene-induced replicative stress
SA Hills, JFX Diffley - Current biology, 2014 - cell.com
DNA replication must be tightly regulated to ensure that the genome is accurately duplicated
during each cell cycle. When these regulatory mechanisms fail, replicative stress and DNA …
during each cell cycle. When these regulatory mechanisms fail, replicative stress and DNA …
DNA replication in eukaryotic cells
SP Bell, A Dutta - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract The maintenance of the eukaryotic genome requires precisely coordinated
replication of the entire genome each time a cell divides. To achieve this coordination …
replication of the entire genome each time a cell divides. To achieve this coordination …
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
M Welcker, BE Clurman - Nature Reviews Cancer, 2008 - nature.com
Abstract FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition
component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein) …
component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein) …
Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication …
Evidence obtained from studies with yeast and Xenopusindicate that the initiation of DNA
replication is a multistep process. The origin recognition complex (ORC), Cdc6p, and …
replication is a multistep process. The origin recognition complex (ORC), Cdc6p, and …
The Ubiquitin–Proteasome System of Saccharomyces cerevisiae
Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …
SCF and Cullin/Ring H2-based ubiquitin ligases
RJ Deshaies - Annual review of cell and developmental biology, 1999 - annualreviews.org
▪ Abstract Protein degradation is deployed to modulate the steady-state abundance of
proteins and to switch cellular regulatory circuits from one state to another by abrupt …
proteins and to switch cellular regulatory circuits from one state to another by abrupt …
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
SCF ubiquitin ligases target phosphorylated substrates for ubiquitin-dependent proteolysis
by means of adapter subunits called F-box proteins. The F-box protein Cdc4 captures …
by means of adapter subunits called F-box proteins. The F-box protein Cdc4 captures …
An overview of Cdk1-controlled targets and processes
The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …
model organism S. cerevisiae. Research performed during the past decade has significantly …
Mechanisms and regulation of DNA replication initiation in eukaryotes
Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …