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Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …
Advances in pluripotent stem cells: history, mechanisms, technologies, and applications
Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …
milestones have driven basic, translational, and clinical advances in the field of stem cell …
Chemical reprogramming of human somatic cells to pluripotent stem cells
Cellular reprogramming can manipulate the identity of cells to generate the desired cell
types,–. The use of cell intrinsic components, including oocyte cytoplasm and transcription …
types,–. The use of cell intrinsic components, including oocyte cytoplasm and transcription …
Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming
S Liuyang, G Wang, Y Wang, H He, Y Lyu, L Cheng… - Cell Stem Cell, 2023 - cell.com
We recently demonstrated the chemical reprogramming of human somatic cells to
pluripotent stem cells (hCiPSCs), which provides a robust approach for cell fate …
pluripotent stem cells (hCiPSCs), which provides a robust approach for cell fate …
Chemical reprogramming for cell fate manipulation: methods, applications, and perspectives
J Wang, S Sun, H Deng - Cell Stem Cell, 2023 - cell.com
Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate
and generate desired cell types including pluripotent stem cells for applications in …
and generate desired cell types including pluripotent stem cells for applications in …
Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade
Somatic cell reprogramming provides insight into basic principles of cell fate determination,
which remain poorly understood. Here we show that the transcription factor Glis1 induces …
which remain poorly understood. Here we show that the transcription factor Glis1 induces …
Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies
P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …
approach for the treatment of cardiovascular diseases. Since the first transplantation into …
Single-cell RNA-seq reveals dynamic early embryonic-like programs during chemical reprogramming
Chemical reprogramming provides a powerful platform for exploring the molecular dynamics
that lead to pluripotency. Although previous studies have uncovered an intermediate …
that lead to pluripotency. Although previous studies have uncovered an intermediate …
In vivo reprogramming for CNS repair: regenerating neurons from endogenous glial cells
Neuroregeneration in the CNS has proven to be difficult despite decades of research. The
old dogma that CNS neurons cannot be regenerated in the adult mammalian brain has been …
old dogma that CNS neurons cannot be regenerated in the adult mammalian brain has been …
In vivo chemical reprogramming of astrocytes into neurons
Y Ma, H **e, X Du, L Wang, X **, Q Zhang, Y Han… - Cell discovery, 2021 - nature.com
In mammals, many organs lack robust regenerative abilities. Lost cells in impaired tissue
could potentially be compensated by converting nearby cells in situ through in vivo …
could potentially be compensated by converting nearby cells in situ through in vivo …