Opioid use disorder (OUD) looms as one of the most severe medical crises facing society.
More effective therapeutics will require a deeper understanding of molecular changes …

Addiction is a leading cause of disease burden worldwide and remains a challenge in
current neuroscience research. Drug-induced lasting changes in gene expression are …

Drugs of abuse increase extracellular concentrations of dopamine in the nucleus
accumbens (NAc), resulting in transcriptional alterations that drive long-lasting cellular and …

Exercise has beneficial effects on cognition throughout the lifespan. Here, we demonstrate
that specific exercise patterns transform insufficient, subthreshold training into long-term …

Cocaine use disorder (CUD) is a chronic neuropsychiatric condition that results from
enduring cellular and molecular adaptations. Among substance use disorders, CUD is …

Rates of individuals struggling with psychostimulant use disorder (PSUD), defined as
chronic use of psychostimulants despite negative consequences, are growing rapidly over …

Methamphetamine use disorder (MUD) is characterized by loss of control over compulsive
drug use. Here, we used a self-administration (SA) model to investigate transcriptional …

Structural and functional changes of the brain are assumed to contribute to excessive
cocaine intake, craving, and relapse in cocaine use disorder (CUD). Epigenetic and …

It has been previously established that paternal development of a strong incentive
motivation for cocaine can predispose offspring to develop high cocaine-seeking behavior …

Understanding time-series interplay of genes is essential for diagnosis and treatment of
disease. Spatio-temporally enriched NGS data contain important underlying regulatory …