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Functional specialization of different PI3K isoforms for the control of neuronal architecture, synaptic plasticity, and cognition
Neuronal connectivity and activity-dependent synaptic plasticity are fundamental properties
that support brain function and cognitive performance. Phosphatidylinositol 3-kinase (PI3K) …
that support brain function and cognitive performance. Phosphatidylinositol 3-kinase (PI3K) …
Decreased CNNM2 expression in prefrontal cortex affects sensorimotor gating function, cognition, dendritic spine morphogenesis and risk of schizophrenia
DY Zhou, X Su, Y Wu, Y Yang, L Zhang… - …, 2024 - nature.com
Genome-wide association studies (GWASs) have reported multiple single nucleotide
polymorphisms (SNPs) associated with schizophrenia, yet the underlying molecular …
polymorphisms (SNPs) associated with schizophrenia, yet the underlying molecular …
[HTML][HTML] Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model
I Serra, OR Manusama, FMP Kaiser, II Floriano… - Brain, Behavior, & …, 2021 - Elsevier
Abstract The phosphoinositide-3-kinase (PI3K) family plays a major role in cell signaling and
is predominant in leukocytes. Gain-of-function (GOF) mutations in the PIK3CD gene lead to …
is predominant in leukocytes. Gain-of-function (GOF) mutations in the PIK3CD gene lead to …
[PDF][PDF] The Role of Phosphoinositide 3-kinases and Rac GTPases in Vascular Inflammation
H Chaudhry - 2022 - kclpure.kcl.ac.uk
ABSTRACT Phosphoinositide-3 kinases and Rac GTPases play important roles in a wide
variety of cellular responses downstream of cell surface receptors. Although their activation …
variety of cellular responses downstream of cell surface receptors. Although their activation …
Autism spectrum disorder: molecular profiling analysis and identification of candidate genes through complex Systems Biology approaches
L Díaz Beltrán - 2021 - ruja.ujaen.es
Autism spectrum disorders (ASD) encompass a wide range of neurological and
developmental conditions characterized by alterations in social skills, repetitive behaviors …
developmental conditions characterized by alterations in social skills, repetitive behaviors …
[KNJIGA][B] Abnormalities in the AKT-mTOR Signaling Pathway in the Dorsolateral Prefrontal Cortex in Schizophrenia
R Chadha - 2020 - search.proquest.com
Schizophrenia (SZ) is a complex and heterogeneous mental illness in which myriad
changes across multiple neurotransmitter systems (dopamine, serotonin, GABA, glutamate …
changes across multiple neurotransmitter systems (dopamine, serotonin, GABA, glutamate …