Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction and repetitive …

The molecular components of the postsynaptic density (PSD) in excitatory synapses of the
brain are currently being investigated as one of the major etiologies of neurodevelopmental …

Parkinson's disease (PD) is a common neurodegenerative disorder with prominent loss of
nigro‐striatal dopaminergic neurons. The resultant dopamine (DA) deficiency underlies the …

The GRIN2B-related neurodevelopmental disorder is a rare disease caused by mutations in
the GRIN2B gene, which encodes the GluN2B subunit of NMDA receptors. Most individuals …

The Dlg4 gene encodes for post-synaptic density protein 95 (PSD95), a major synaptic
protein that clusters glutamate receptors and is critical for plasticity. PSD95 levels are …

Abstract Postsynaptic density protein-95 (PSD-95) is a major regulator in the maturation of
excitatory synapses by interacting and trafficking N-methyl-D-aspartic acid receptors …

Autism spectrum disorder (ASD) comprises a range of neurological conditions that affect
individuals' ability to communicate and interact with others. People with ASD often exhibit …

Background Hyperexcitability of neuronal networks can lead to excessive release of the
excitatory neurotransmitter glutamate, which in turn can cause neuronal damage by …

Schizophrenia is a chronic disease presented with psychotic symptoms, negative symptoms,
impairment in the reward system, and widespread neurocognitive deterioration. Disruption …