Over the decades, various interventions have been developed and utilized to treat epilepsy.
However, the majority of epileptic patients are often first prescribed anti-epileptic drugs …

Propionate, a short-chain fatty acid, serves important roles in the human body. However, our
review of the current literature suggests that under certain conditions, excess levels of …

Glioma, characterized by infiltrative growth and treatment resistance, is regarded as the most
prevalent intracranial malignant tumor. Due to its poor prognosis, accumulating investigation …

Hyperammonaemia (HA) as a consequence of numerous primary or secondary causes,
gives rise to clinical manifestations due to its toxic effects on the brain. The neurological …

Seizure-and epilepsy-related complications are a common cause of emergency medical
evaluation, accounting for 5% of 911 calls and 1% of emergency department visits …

Background Hyperammonemia is an adverse effect that poses clinical uncertainty around
valproic acid (VPA) use. The prevalence of symptomatic and asymptomatic …

The urea cycle (UC) is a critically important metabolic process for the disposal of nitrogen
(ammonia) produced by amino acids catabolism. The impairment of this liver-specific …

Introduction: Hyperammonemia and hepatotoxicity are well-known complications of valproic
acid (VPA) poisoning. The objective of this study is to evaluate the potential role of carnitine …

Objective Valproic acid (VPA)-induced hyperammonemia (VIH), is an increase in blood
ammonia levels without any alteration of hepatic enzymes, which can occur during VPA …

Valproic acid (VPA) is a short-chain fatty acid widely prescribed in the treatment of seizure
disorders and epilepsy syndromes, although its therapeutic value may be undermined by its …