Asymmetric flow field-flow fractionation in the field of nanomedicine

M Wagner, S Holzschuh, A Traeger, A Fahr… - Analytical …, 2014‏ - ACS Publications
Asymmetric flow field-flow fractionation (AF4) is a widely used and versatile technique in the
family of field-flow fractionations, indicated by a rapidly increasing number of publications. It …

[HTML][HTML] Field-flow fractionation for molecular-interaction studies of labile and complex systems: A critical review

IK Ventouri, S Loeber, GW Somsen… - Analytica chimica …, 2022‏ - Elsevier
Asymmetrical flow field-flow fractionation (AF4) has attracted considerable attention as a
size-based separation technique, due to its mild separation conditions, broad working range …

Proteins and antibodies in serum, plasma, and whole blood—size characterization using asymmetrical flow field-flow fractionation (AF4)

M Leeman, J Choi, S Hansson, MU Storm… - Analytical and …, 2018‏ - Springer
The analysis of aggregates of therapeutic proteins is crucial in order to ensure efficacy and
patient safety. Typically, the analysis is performed in the finished formulation to ensure that …

Separation and characterization of extracellular vesicles from human plasma by asymmetrical flow field-flow fractionation

B Wu, X Chen, J Wang, X Qing, Z Wang, X Ding… - Analytica Chimica …, 2020‏ - Elsevier
It is a big challenge to isolate extracellular vesicles (EVs) from human plasma because of
the contamination from high abundant lipoproteins, such as high density lipoprotein (HDL) …

Dielectrophoresis-field flow fractionation for separation of particles: A critical review

W Waheed, OZ Sharaf, A Alazzam… - Journal of Chromatography …, 2021‏ - Elsevier
Dielectrophoresis-field flow fractionation (DEP-FFF) has emerged as an efficient in-vitro, non-
invasive, and label-free mechanism to manipulate a variety of nano-and micro-scaled …

Probing protein denaturation during size-exclusion chromatography using native mass spectrometry

IK Ventouri, DBA Malheiro, RLC Voeten, S Kok… - Analytical …, 2020‏ - ACS Publications
Size-exclusion chromatography employing aqueous mobile phases with volatile salts at
neutral pH combined with electrospray-ionization mass spectrometry (SEC-ESI-MS) is a …

Analysis of proteins, protein complexes, and organellar proteomes using sheathless capillary zone electrophoresis-native mass spectrometry

AM Belov, R Viner, MR Santos, DM Horn… - Journal of The …, 2017‏ - ACS Publications
Native mass spectrometry (MS) is a rapidly advancing field in the analysis of proteins,
protein complexes, and macromolecular species of various types. The majority of native MS …

Understanding the Physical Interactions in the FGF21/FGFR/β‐Klotho Complex: Structural Requirements and Implications in FGF21 Signaling

J Yie, W Wang, L Deng, LT Tam… - Chemical biology & …, 2012‏ - Wiley Online Library
The endocrine fibroblast growth factor 21 (FGF21) requires both fibroblast growth factor
receptor (FGFR) and β‐Klotho for signaling. In this study, we sought to understand the inter …

Surface-induced dissociation of ion mobility-separated noncovalent complexes in a quadrupole/time-of-flight mass spectrometer

M Zhou, C Huang, VH Wysocki - Analytical chemistry, 2012‏ - ACS Publications
A custom in-line surface-induced dissociation (SID) device has been incorporated into a
commercial ion mobility quadrupole/time-of-flight mass spectrometer in order to provide an …

Field-flow fractionation: New and exciting perspectives in polymer analysis

MI Malik, H Pasch - Progress in Polymer Science, 2016‏ - Elsevier
The development of advanced polymeric materials requires state-of-the-art synthesis and
molecular characterization protocols. Only the precise knowledge of molecular structure …