Simple Summary Microfluidic-based cancer-on-a-chip models are powerful tools to study the
tumor microenvironment (TME). Two-dimensional cell culture cannot recapitulate TME. In …

Liquid biopsy has seen tremendous progress over the past decade as it represents a
potential innovative solution to several limitations of current cancer management. By …

During metastasis, all cancer types must migrate through crowded multicellular
environments. Simultaneously, cancers appear to change their biophysical properties …

Abstract Background Prostate cancer (PCa) is usually considered as cold tumor. Malignancy
is associated with cell mechanic changes that contribute to extensive cell deformation …

We have developed a deformability cytometer that simultaneously measures the optical and
electrical shape change of single cells in a viscoelastic shear flow. The optical deformability …

Heterogeneities among tumor cells significantly contribute towards cancer progression and
therapeutic inefficiency. Hence, understanding the nature of cancer through liquid biopsies …

The mechanical properties of single cells have been recognized as biomarkers for
identifying individual cells and diagnosing human diseases. Microfluidic devices based on …

Castration-resistant prostate cancer remains a significant clinical challenge, wherein
patients display no response to existing hormone therapies. The standard of care often …

Prostate cancer is a disease in which cells in the prostate, a gland in the male reproductive
system below the bladder, grow out of control and, among men, it is the second-most …

Microfluidic systems aim to detect sample matter quickly with high sensitivity and resolution,
on a small scale. With its increased use in medicine, the field is showing significant promise …