Microtubules and microtubule-associated proteins

HV Goodson, EM Jonasson - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Microtubules act as “railways” for motor-driven intracellular transport, interact with accessory
proteins to assemble into larger structures such as the mitotic spindle, and provide an …

The cytoskeleton—a complex interacting meshwork

T Hohmann, F Dehghani - Cells, 2019 - mdpi.com
The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Microtubules acquire resistance from mechanical breakage through intralumenal acetylation

Z Xu, L Schaedel, D Portran, A Aguilar, J Gaillard… - Science, 2017 - science.org
Eukaryotic cells rely on long-lived microtubules for intracellular transport and as
compression-bearing elements. We considered that long-lived microtubules are acetylated …

Building the neuronal microtubule cytoskeleton

LC Kapitein, CC Hoogenraad - Neuron, 2015 - cell.com
Microtubules are one of the major cytoskeletal components of neurons, essential for many
fundamental cellular and developmental processes, such as neuronal migration, polarity …

Tubulin acetylation protects long-lived microtubules against mechanical ageing

D Portran, L Schaedel, Z Xu, M Théry, MV Nachury - Nature cell biology, 2017 - nature.com
Long-lived microtubules endow the eukaryotic cell with long-range transport abilities. While
long-lived microtubules are acetylated on Lys40 of α-tubulin (αK40), acetylation takes place …

Application of exact continuum size-dependent theory for stability and frequency analysis of a curved cantilevered microtubule by considering viscoelastic properties

A Shariati, M Habibi, A Tounsi, H Safarpour… - Engineering with …, 2021 - Springer
The stability analysis of cantilevered curved microtubules in axons regarding various size
elements and using the generalized differential quadrature method for solving equations is …

Microtubules self-repair in response to mechanical stress

L Schaedel, K John, J Gaillard, MV Nachury… - Nature materials, 2015 - nature.com
Microtubules—which define the shape of axons, cilia and flagella, and provide tracks for
intracellular transport—can be highly bent by intracellular forces, and microtubule structure …

Microtubule-severing enzymes: From cellular functions to molecular mechanism

FJ McNally, A Roll-Mecak - Journal of Cell Biology, 2018 - rupress.org
Microtubule-severing enzymes generate internal breaks in microtubules. They are
conserved in eukaryotes from ciliates to mammals, and their function is important in diverse …

Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks

L Zhang, JB Bailey, RH Subramanian, A Groisman… - Nature, 2018 - nature.com
The formation of condensed matter typically involves a trade-off between structural order
and flexibility. As the extent and directionality of interactions between atomic or molecular …

Emergent complexity of the cytoskeleton: from single filaments to tissue

F Huber, J Schnauß, S Rönicke, P Rauch… - Advances in …, 2013 - Taylor & Francis
Despite their overwhelming complexity, living cells display a high degree of internal
mechanical and functional organization which can largely be attributed to the intracellular …